forzajuve wrote:I've searched this site and others.
Over a year ago I heard alot about people having their Immune System Rebooted and it showing results in very early trials. People had chemotherapy to destroy their immune system and retransplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems.
My question in does CCSVI and the above theory make any sense together?
Does one have to be wrong?
It's an interesting question. In one of the long CCSVI discussion threads I believe there was some speculation that in addition to getting venous issues resolved, rebooting or at least dampening the immune system for awhile, might theoretically help healing, at least in some cases. Again, just speculation.
Personally I've always been of the opinion that the immune system is not the villain it's often made out to be in MS. I think it's probably doing exactly what it's supposed to do and trying to clean up whatever underlying problem is going on... damage resulting from poor blood flow, excess iron deposits, bacteria, virus, whatever. Maybe even different underlying problems for different subsets of MS patients?
I always wondered if high dose chemotherapy not only reset the immune system, but somehow resolved the underlying problem in those it was successful for. Maybe makes sense if the problem was a long standing bacterial infection for example. Not sure how that would fit with the CCSVI paradigm though.
As bestadmom pointed out, chemo was/is not successful for everyone.
Again; all just speculation, and very simplistic speculation at that.
But as long as I'm speculating...
If CCSVI is proven to be the underlying problem in MS, will fixing it be enough to "reset" the immune system and stop an established pattern of involvement? If so, theoretically progression should stop and our focus could then be on repair. Wouldn't that be amazing!
Or will there still need to be some kind of clean-up of existing damage and/or retraining of the immune system before it backs off?
I'm excited about CCSVI research, but it is very early, and there are lots of questions still to be answered.
There is at least one TIMS member who has had both treatment with Revimmune and surgery to correct CCSVI. Check the first page of the CCSVI tracking project
thread for a post by Jamie re: Melissa. Last I read Jamie wasn't planning on hanging out here as much as in the past since Mel was continuing to do well and they were getting on with their lives. Very good news! Hopefully he will still pop in occasionally to keep us updated.