While neurology professor Lawrence Steinman, MD, senior author of the new study, cautioned that extensive clinical trial work is needed to determine if the drug, known as lisinopril, can do in humans what it does in mice, he is excited that "we were able to show that all the targets for lisinopril are there and ready for therapeutic manipulation in the multiple-sclerosis lesions of human patients. Without that, this would be just another intriguing paper about what's possible in the mouse."
japentz wrote:NOTE: I do not condone the use of beta blockers due to possible bad coughing side effects. I AM interested in hearing from people who also have high blood pressure and any effects that betablockers or Angiotensin Receptor Blockers (ARBs) might have on their MS if they take them
I had read an article by Bruce Goldman, a journalist for the Stanford School of Medicine regarding Dr. Lawrence Steinman's research which involved giving mice with and MS like disease, the beta blocker Lisinopril. Beta blockers (as you may know) are medication for high blood pressure. The mice walked again.
RRMS, Diagnosed July 2008
Baltimore, MD USA
And before everyone runs out to ask for the "... inexpensive, safe pharmaceuticals used by millions worldwide..." they might want to consider the possibility that it may be contraindicated in your particular medical case and screwing around with your BP may be dangerous for you.
Although the treatment of high blood pressure has generally been a hit/miss/tryanotherdrug/miss/tryanotherdrug thing in the past (kinda like treating MS), now there's a machine that can tell them quickly where your problem lies and choose the best med for it - the Bio-Z machine. For example, it told them that the beta blocker I'd been taking was doing its job in that area and that my fluids were fine and I don't need to add a diuretic. It also said that I DO need to add something like an ACE inhibitor, but the side effects have prevented me from taking one.
Logically, the mouse walking again, would have nothing to do with Lisinopril helping CCSVI, as current "mice with an MS like disease" have nothing to do with human MS (if you go by CCSVI), its EAE which is an Auto-immune condition.japentz wrote:I had read an article by Bruce Goldman, a journalist for the Stanford School of Medicine regarding Dr. Lawrence Steinman's research which involved giving mice with and MS like disease, the ace inhibitor Lisinopril. Beta blockers (as you may know) are medication for high blood pressure. The mice walked again.
So I believe that 'opening up' veins may help. I am interested in hearing others experiences.
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