Dr. Rudick and colleagues at the Cleveland Clinic, who have been following 85 MS patients and healthy controls since 2000, reported in the July 15 Journal of Neurological Science that the gray matter volume in patients decreases over time. Early in the disease, Dr. Rudick said, gray matter volume loss proceeds three times faster in patients than in controls.As the disease progresses — and the symptoms worsen — “the rate of atrophy in patients increases to 14 times that seen in unaffected people,” Dr. Rudick added. “What's more, gray matter atrophy correlates with physical disability and cognitive disability more strongly than white matter atrophy.”As the evidence for this two-hit hypothesis strengthens, scores of laboratories are trying to find imaging tools to identify gray matter pathology and develop therapies that slow or stop the cortical degeneration. The therapies now in development target white matter pathology. And scientists still have to figure out the relationship between the inflammation in the white matter and the cortical damage.
cheerleader wrote:Hey Mark-
That's a new paper. Thanks. There are five new papers out on gray matter loss and MS from November 2009- present. More and more researchers are finding the link to gray matter loss and disability and progression. We have often noted on here that it's "NOT about the white matter lesions" since many of our members have few or none, and are progressive. This is why it is ESSENTIAL that patients are tested for venous insufficiency and treated before the brain atrophies..
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