One thing that I often think about is who is responsible of the previous defective research into MS. In fact everybody knew that the blood-brain barrier was disrupted before the attacks and that an autoimmune problem cannot cause that, but nobody was researching this.
The current model of research, is lead by big pharmas. As any other company they look for profit. They really have the right to research only fields that will give them profit back, but then, who is responsible to do the primary research?
Universities and associations should fill this gap, but normally they have less resources to invest, and they work in association with pharmas. Again, they end by researching the same fields than pharmas propose which are not primary research.
Finally if somebody independent does primary research, obviously he cannot afford the same amount of time and resources than the mainstream, and his work will be ignored by the rest.
I really think that the ones that are not doing their work are universities and associations, but nobody can control what they do. Also doctors, because they prescribe blindly, only with the FDA approval (which is required by medicaments, but they do not need FDA approval to prescribe diets or lifestile)
I want to add that since a long time ago the MS research is the opposite of science. Normally an hypothesis is proposed, and then the community works to invalidate it (an hypothesis will never be valid for sure). There is enough information since a long time ago to say that the autoimmune theory is invalid, even if there is immune involvement in the lesions, but nobody wanted to state that clearly by the pharma interest.