I have also had neg. LP's... Two of them to be exact and they both sucked very much, might I add. I was still given steroids and my DX was still MS. It was my understanding tho that you will only see oligoclonal bands IF you have active inflammation?? Now what amazes me is that we can have lesions and the tests don't reflect it.. But the MRI's clearly show them... so why bother with them anyway??
As far as BBB breach goes, I believe ccsvi creates the actual breach to begin with. I thought immune cells freely passed between the CNS and the rest of the body anyway? Tysabri's mechanism is by adhesion molecules.. The drug attaches itself to so called "rouge" immune cells.. This attachment now makes them too large to pass accross the bbb. So, if the increased iron / oxygen depleted blood wasn't there in the first place, the immune response would not have occurred? Right?
Here is the $50k question though... Open up, the blockage (relieve the pressure which causes the breach).. Eliminate the reason for the immune response... Now how do we get out the iron that has already crossed... reverse CNS reflux???