mrtmeo wrote:I don't know if giving her more D3 would lower the PTH and bring up her calcium even tho she can't drink the required amount of fluids per day due to the kidneys not converting it or what.
mrtmeo wrote: and if I gave her a superdose of 100,000 iu's for 2 days, her calcium would rise above normal and I would have to stop.
Lionel wrote:Your mother could try this spray vitamin D product: https://betteryou.com/dlux3000
DLux3000 vitamin D oral spray is able to guarantee a level of absorption that no other supplement can match.
Our digestive efficiency is not always assured, particularly when we are unwell or out of sorts, DLux3000 by-passes the digestive system offering the fastest and most effective delivery mechanism available.
Research by Cardiff University has shown that by applying it directly into the mouth, ideally under the tongue or on the inside of the cheek, it is absorbed directly through the mucous membrane into the blood system. This ensures no loss during the absorption process. The solution has been micro emulsified to ensure the particle size is optimal for absorption in this way.
The levels of 1,25-vitamin D (the active form of vitamin D) generally increase for patients following Coimbra Protocol.
My brother's 1,25-vitamin D level increased 48,0 pg/mL (2015 when he started the protocol) to 135 pg/mL (2017).
Although, in some cases, it does not change so much.
It is important to remember that patients with autoimmune diseases need to take a lot 25-vitamin D to produce/maintain the active form (1,25-vitamin D) in normal levels.
However, there is a trick here.... If you have vitamin D deficiency the 1,25 levels can also be at normal or even elevated.
Dr. Michael Holick (vitamin D leading authority ) writes about it in his book and also about kidney problems and vitamin D3 supplementation. I'll quote him:
"The active form of vitamin D circulates at one thousand times lower concentration than 25-vitamin D, which, when created by your body from a supplement, has a half-life in your circulation of two to three weeks. The 25-vitamin D made by your body in response to sunlight, however, lasts twice as long in the body. Half-life simply refers to the amount of time it takes the body to eliminate one half of the total amount of 25-vitamin D and 1,25-vitamin D in your blood. On the other hand, the active form of vitamin D has a half-life of only two to four hours, meaning that the concentration of active D in your bloodstream is reduced by half every two to four hours.
As you become vitamin D deficient, the body immediately responds by increasing the production of parathyroid hormone, which tells your kidneys to activate vitamin D, which is why your activated vitamin D (1,25-vitamin D) levels are either normal or elevated when you are vitamin D deficient or insufficient.
How is that possible? And how can you be vitamin D deficient if the kidneys then crank out more activated D? My guess is that your target tissues, namely your intestines and bones, still can’t get enough, even though your blood levels are normal. Serum calcium is usually normal in the vitamin D-deficient state. Most physicians also trip up on calcium levels.
That is to say, if they measure calcium levels in the blood and see nothing off the mark, they automatically assume this translates to a corresponding normal vitamin D status. But in fact this isn’t necessarily true. Neither calcium levels nor activated vitamin D levels in the blood can tell you whether or not you are vitamin D deficient. You must measure 25-vitamin D; do not accept any other marker no matter what your doctor tells you"
"Kidney failure. Severe kidney disease can interfere with the conversion of 25-vitamin D to activated vitamin D. But someone with compromised kidneys would still need adequate vitamin D to benefit from all its other health benefits and support the local production of activated vitamin D in parathyroid glands to help control the parathyroid hormone levels, which usually increase in patients with stages 4 and 5 kidney disease"
"Question: I have kidney disease and am on dialysis. My doctor said that since my kidneys cannot make activated vitamin D from 25-vitamin D, there is no need for me to take vitamin D to maintain my blood levels of 25-vitamin D above 30 nanograms per milliliter. Is this correct?
Answer: No. The National Kidney Foundation and I recommend that all patients with kidney failure—even patients with no kidneys—should maintain 25-vitamin D levels of 30 to 100 nanograms per milliliter" 
It's important to be aware that when he wrote this book he did not know about Coimbra Protocol. Because, in most cases, 30 to 100 nanograms per milliliter is not enough to stop an autoimmune diseases.
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