Vitamin D resistance

A forum to discuss the Coimbra Protocol which uses high-dose vitamin D3 to treat multiple sclerosis.

Vitamin D resistance

Postby mrtmeo » Sun Apr 02, 2017 5:23 am

Is the goal with the vitamin D protocol to overcome resistance of 25 hydroxy D (storage D) conversion to 1,25 dihydroxy D (active D) or is it resistance on a cellular level?
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
mrtmeo
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Re: Vitamin D resistance

Postby AntonioBR » Sun Apr 02, 2017 11:49 am

mrtmeo wrote:Is the goal with the vitamin D protocol to overcome resistance of 25 hydroxy D (storage D) conversion to 1,25 dihydroxy D (active D) or is it resistance on a cellular level?


Well, the resistance happens in a genetic level.

By genetic mutations, alteration of the genetic code itself... Or/and changes caused by modification of gene expression (epigenetic factor).

The exact mechanism of this resistance is not clear yet.

Second Coimbra the resistance may also be due to an alteration of the enzymes dealing with the conversion and activation of vitamin D, which are two hydroxylases. So there are many different possibilities. The effect of such genetically altered vitamin D metabolism happens on several diseases - not only autoimmune disorders.

The epigenetic hypothesis for some diseases seems very interesting and very plausible.
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Re: Vitamin D resistance

Postby mrtmeo » Mon Apr 03, 2017 7:30 am

I guess I am looking at it from the perspective of if the acitve D form never gets high enuf no matter how much D the person takes, will this keep the person from obtaining remission or is it problem with VDRs themselves?

Yes, epigenitics explains it all how our environment has everything to do with our gene expressions.
Mother was on Rituximab and prednisone for Microscopic Polyangiitis which attacked the kidneys and lungs.
Drs denied her dialysis and appropriate treatment for her MPA and forced her into hospice.
She is in heaven and free from pain.
mrtmeo
Family Elder
 
Posts: 119
Joined: Sun Aug 28, 2016 4:44 pm
Location: Wisconsin, USA

Re: Vitamin D resistance

Postby AntonioBR » Mon Apr 03, 2017 8:32 am

mrtmeo wrote:I guess I am looking at it from the perspective of if the acitve D form never gets high enuf no matter how much D the person takes, will this keep the person from obtaining remission or is it problem with VDRs themselves?


It happens with both healthy people and those who have autoimmune diseases. The 1,25-vitamin D form ''almost'' does not change even if you take high doses of vit.D.

It is related with VDRs. And PTH - until now - it is the better form to measure it.


By the way talking about epigenetics there is a study published in march 29, 2017

Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0174726
AntonioBR
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Posts: 500
Joined: Sat Dec 12, 2015 11:06 am


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