As far as my experience has been it is just luck as to who will develop lipoatrophy - or at least, it is due to something that SS have not yet told us about or discovered.
I have been on Copaxone for nearly 6 years, 5 years Rebif before that. I developed only one tiny lipo area on Rebif.
On Copaxone my legs, butt, lower back and stomach are really destroyed with extensive lipo....but I am still persevering with Copaxone because my MS has improved over the time I've been on it. If anything it continues to improve, so it's lipo vs. good health, I feel.
I ALWAYS rotated. I had something like 55+ sites during Rebif and about 40+ sites on Copaxone and I keep a diary. I think lipo has NOTHING to do with rotating and I'm angry with Teva that they keep trotting out the BS about rotation....I think they know that is not the reason lipo happens.
RR-MS dx 1998 and Coeliac dx 2003
Copaxone, Cymbalta. EPO, Fish Oils, Vitamin D3 2000 IU daily, Cal/Mag/Zinc, Multivitamin/mineral, Co-Enzyme Q10, Probiotics, Milk Thistle.