Glatiramer acetate (Copaxone) induced hepatotoxicity

A board to discuss the Multiple Sclerosis modifying drug Copaxone

Glatiramer acetate (Copaxone) induced hepatotoxicity

Postby MSUK » Fri Aug 10, 2012 6:20 am


Introduction: Glatiramer acetate (Copaxone), a polypeptide has been approved for treating patients with active relapsing-remitting multiple sclerosis.

Case Presentation: We report the first case of severe acute hepatitis after commencing treatment for multiple sclerosis with glatiramer acetate.

A 31-year-old female with multiple sclerosis presented with anorexia, lethargy and jaundice five weeks after commencing glatiramer acetate. She had never received beta-interferon treatment. Investigations revealed a bilirubin of 0.109 mmol/L (0.002-0.02 mmoL/L) and prothrombin time of 21 secs (9-15 secs). Her liver function tests were normal before commencing glatiramer acetate. ... Read More - ... ageid/1767
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