I have been on copaxone over 10 years. I believe I have gone secondary progressive. In 10 years on copaxone I had no major relapses. However, over the past year or two my legs have started degrading. I tried adding LDN and had my first relapse in 10 years. The copaxone hasn't caused the fatigue and weakness in my legs, that is the MS. What it has done is keep relapses away. I still have use of everything, which may not be the case without copaxone.