I called his MS nurse behind his back (since he's asleep anyway) and she said it might be because he's giving his injections too late at night (about an hour before bed) But this has been going on every night and his injections are only every second night.
It sounds like he's on Betaseron, is that correct? If so, then I agree with his nurse's statement. I find that I do much better if I have my interferon shot around noon. I experience less side effects and less fatigue the next day. Though be sure to keep some ibuprofen around to counter the side effects.
I also have chronic neuropathic pain in my foot. It often keeps me from falling asleep for an hour or up to two sometimes. I find that the pain is not as bad if I try to sleep on my side and not on my back. Perhaps there's something that can be done with sleeping position that can help your husband?