They are "true" relapses. This is not my opinion, it is my neurologists. I've also had many "pseudo" relapses due to an appendectomy and a few minor illnesses, so I can mostly tell the difference.
As I said, I am taking vitamin D; my level was tested when I was first assesed and diagnosed, and is/will be retested at regular intervals.
Vitamin D and calcium deficits predispose for multiple chronic diseases
There is evidence from both observational studies and clinical trials that calcium malnutrition and hypovitaminosis D are predisposing conditions for various common chronic diseases. In addition to skeletal disorders, calcium and vitamin D deficits increase the risk of ... multiple sclerosis), as well as of metabolic disorders... The aim of the present review was to provide improved understanding of the molecular and cellular processes by which deficits in calcium and vitamin D cause specific changes in cell and organ functions and thereby increase the risk for chronic diseases of different aetiology...
... attenuation of signal transduction from the ligand-activated vitamin D receptor and calcium-sensing receptor seems to be the prime mechanism by which calcium and vitamin D insufficiencies cause perturbation of cellular functions in bone, kidney, intestine, mammary and prostate glands, endocrine pancreas, vascular endothelium, and, importantly, in the immune system...
Magnesium Absorption: Mechanisms and the Influence of Vitamin D, Calcium and Phosphate1
...Pharmacological doses of vitamin D increase Mg absorption in both vitamin D-deficient and vitamin D-replete animals. A substantial amount of Mg absorption, however, occurs independent of vitamin D. In addition, vitamin D may reduce Mg retention through increases in urinary Mg excretion. Intestinal interactions between Mg and calcium or phosphate have been demonstrated in both humans and animals. The nature of these interactions cannot be readily explained by data currently available.
Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency
Vitamin D insufficiency is common, however within individuals, not all manifest the biochemical effects of PTH excess. ... The mechanism underlying the blunted PTH response is unclear but may be related to magnesium (Mg) deficiency. ... All subjects, within the low vitamin D and low PTH group following the magnesium loading test had evidence of Mg depletion [mean(SD) retention 70.3%(12.5)] and showed an increase in calcium 0.06(0.01) mmol/l [95% CI 0.03, 0.09, p=0.007], together with a rise in PTH 13.3 ng/l (4.5) [95% CI 3.2, 23.4, p=0.016] compared to baseline. ... This study confirms that in patients with established osteoporosis, there is also a distinct group with a low vitamin D and a blunted PTH level and that Mg deficiency (as measured by the Mg loading test) is an important contributing factor.
Enhancement of vitamin D3 effect on bone metabolism in weanling rats orally administered zinc sulphate
Masayoshi Yamaguchi and Teruyuki Sakashita
Abstract. The interaction of vitamin D3 and zinc on bone metabolism was investigated in the femur of weanling rats. ... At a dose of 0.5 µg of vitamin D3 per 100 g, DNA content was at the control level. This level was increased about 2 times by simultaneous administration of zinc (1.0 mg/100 g). ... The present data suggest that the combination of vitamin D3 and zinc has a multiple effect on the stimulation of bone growth and mineralization in weanling rats, and that this effect is based on a stimulation of the DNA synthesis in bone cells.
Users browsing this forum: No registered users