I have had lots of sleep problems. I have tried various things. I kind of settled on a few things. Lorazepam, tylenol or advil night-time formulas and gravol. These night-time formulas are usually pain-killer mixed with a decongestant, which is the sleep medication part. Because I do not want dependency on anything to develop, and all of the above can be habit-forming, I alternate from night to night. Each of these things has its own pluses and minuses. I would take lorazepam if I felt particularly anxious for some reason, as it is a good tranquilizer. The pain medications can help reduce inflammation. Watch out for grogginess after you wake up, and anything for sleep does not mix with driving, drinking, or operating heavy machinery. Unless you *want* to have an accident.
Lately though, I am in the habit, which does not seem habitual, of taking a quarter tablet of seraquil at bedtime. If I do this before midnight, I am fine for the night. If I take it after that, I am too groggy in the morning. It works just as well day after day. It is an anti-anxiety drug, but different from lorazepam.
Melatonin is released naturally, and it is part of why we are not nocturnal. It is released at sundown, and should make you sleep (the natural release). It has a daytime counterpart, the release of endorphin at sunup. In my case I believe it was responsible for those automatic morning erections I used to have when younger. It helps you wake up.
LDN is supposed to enhance your endorphin production, which is thought to be low, in diseases like HIV, cancers, crone's and "MS". What you are timkering with here (and by taking melatonin) is your circadian rhythm, which controls daily cycles in your endogenous hormone production.
I am a bit suspicious of LDN for cancer, because it is thought to promote angiogenesis. Angiogenesis is a natural process, but it is definitely part of what turns a precancerous cell into a tumour, when is is acquiring its own blood supply. Angiogenesis may at the same time be a good thing for people with CCSVI, as it is necessary in order for new collateral veins to develop.
One of the objections to melatonin is the size of the dose. 2mg will flood your system with melatonin, and may be like hitting your circadian clock with a sledgehammer. I have read that 0.5 mg is the maximum, but I believe even that is probably way too much.
The absolutely critical thing about taking LDN or melatonin, is that you do it at the same time every day. Best thing to do about bedtime is to make a ritual of it. Always do the same things every day, half an hour to an hour before you go to bed, and always do it at the same time every day. All these circadian things, like eating, sleeping, in some people excreting, having sex, waking up, are part of a delicate daily circadian rhythm, which is easily disturbed.
The worst way to interfere with the daily shut-down cycle is to use artificial light. A close second which throws millions of people way off twice a year, and probably causes many automobile deaths, is Daylight Saving Time. Do not be surprised if sleep troubles come back after the "fall back" happens.
If you are a photo-phobe like I am, you may be aware that a soft red night-light is ok, but blue, green and the short wavelengths of light are more likely to wake you up or keep you awake. That is because our circadian clocks are synchronized by sunlight, which is more in the blue end.
All that is secondary to the most annoying effect of "MS" that I have: I don't dream.
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience