I noticed there wasn't anything further added to your last post on fatigue (specifically, fatigue after some effort). So, I'm going to take a stab. When I had my initial, problems, I saw a GP who recommended an extensive list of supplements. He was a very old man (he retired couple of months later, about 75 I think) and his explanations fo the supplements were sort of vague, but that fact is, everything I have read in the year since then has supported his advice. Except for selenium. I've never seen it mentioned for MS but he recommended I take quite a lot...and take it specifically to help me because I was all wobbley/weak after exercise. I googled and came on couple of reference to selenium which I can't understand. I'm inserting one below NOT because I think its the answer to your fatigue, but suggesting you make sure you're giiving your body everything you can to help it. I am still something weak after exercise, and I'm gonig to keep looking for way to strengthen up, and in particular look at non-ms approaches like body building approaches.
Oh yeah, forgot to mention, the research below iwas on rats. But still. I'm just trying to suggest there are possibilities.
Selenium deficiency, endurance exercise capacity, and antioxidant status in rats.Lang JK, Gohil K, Packer L, Burk RF.
Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Increased O2 metabolism imposed by physical exercise is likely to augment the production of active O2 species that have been shown to react with lipids, proteins, and DNA. Antioxidants and antioxidant enzymes, such as the selenium enzyme glutathione peroxidase, minimize or prevent such potentially toxic reactions. This study shows that selenium deficiency decreases glutathione peroxidase activity in liver and muscle (less than 80%, P less than 0.001), increases total glutathione in liver, muscle, and plasma (P less than 0.05) and increases muscle cytochrome oxidase activity, and ubiquinone content (P less than 0.05) but has no effect on endurance capacity. Exercise to exhaustion resulted in a significant (P less than 0.001) elevation of total and oxidized glutathione (GSSG) and a significant (P less than 0.05) decrease of vitamin E in plasma of control and selenium-deficient rats. Acute exercise also increased tissue GSSG levels in both control and selenium-deficient groups of rats. Hence, despite a large depletion of selenium-deficient glutathione peroxidase, pronounced oxidation of glutathione to GSSG can be produced by the increased oxidative metabolism during physical exercise. The results suggest that the residual glutathione peroxidase activity is sufficient to detoxify hydroperoxides in exercising selenium-deficient animals and to prevent the impairment of endurance capacity.
PMID: 3436884 [PubMed - indexed for MEDLINE]