FYI @ lyndacarol - insulin resistance & magnesium defici

A board to discuss various diet-centered approaches to treating or controlling Multiple Sclerosis, e.g., the Swank Diet

FYI @ lyndacarol - insulin resistance & magnesium defici

Postby jimmylegs » Wed Aug 10, 2011 10:46 am

http://care.diabetesjournals.org/content/28/5/1175.long

Magnesium Deficiency Is Associated With Insulin Resistance in Obese Children

Abstract
OBJECTIVE—Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults. This study was designed to determine whether obese children exhibit serum or dietary magnesium deficiency and its potential association with IR.

RESEARCH DESIGN AND METHODS—We studied 24 obese nondiabetic children (BMI ≥85th percentile) and 24 sex- and puberty-matched lean control subjects (BMI <85th percentile). We measured serum magnesium, indexes of insulin sensitivity, dietary magnesium intake (using a food frequency questionnaire), and body composition (by air displacement plethysmography).

RESULTS—Serum magnesium was significantly lower in obese children (0.748 ± 0.015 mmol/l, means ± SE) compared with lean children (0.801 ± 0.012 mmol/l) (P = 0.009). Serum magnesium was inversely correlated with fasting insulin (rs = −0.36 [95% CI −0.59 to −0.08]; P = 0.011) and positively correlated with quantitative insulin sensitivity check index (QUICKI) (0.35 [0.06–0.58]; P = 0.015). Dietary magnesium intake was significantly lower in obese children (obese: 0.12 ± 0.004 vs. lean: 0.14 ± 0.004 mg/kcal; P = 0.003). Dietary magnesium intake was inversely associated with fasting insulin (−0.43 [−0.64 to −0.16]; P = 0.002) and directly correlated with QUICKI (0.43 [0.16–0.64]; P = 0.002).

CONCLUSIONS—The association between magnesium deficiency and IR is present during childhood. Serum magnesium deficiency in obese children may be secondary to decreased dietary magnesium intake. Magnesium supplementation or increased intake of magnesium-rich foods may be an important tool in the prevention of type 2 diabetes in obese children.

jimmylegs note: only the top end of the range of serum mag in lean kids was actually adequate, ie 0.801 + 0.12 = 0.921 mmol/L. minimum should be 0.90 mmol/L.
jimmylegs
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Re: FYI @ lyndacarol - insulin resistance & magnesium defici

Postby jimmylegs » Fri Sep 16, 2011 4:56 am

hi, i think you might be after the trigger mechanism section here (note the alert and related talk page):

http://en.wikipedia.org/wiki/Insulin_si ... od_glucose

also a video, more about what happens when the presence of elevated glucose triggers the insulin:

http://www.youtube.com/watch?v=FkkK5lTmBYQ

the video is interesting because of the activity of ATP at 2min in (with its links to magnesium, which have been explored previously here at TiMS).

i went looking for Mg-ATP and insulin and found this one (i apologize in advance for this abstract):

Separate effects of Mg2+, MgATP, and ATP4- on the kinetic mechanism for insulin receptor tyrosine kinase
http://www.ncbi.nlm.nih.gov/pubmed/2157363
jimmylegs
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