MScrusade wrote: I mean correct me if im wrong but im 100% sure that the treatment im on (tysabari, or natalizumab) stunts the production of white blood cells and weakens my immune system for the exact purpose of the fact that my immune system is trying to destroy my myline sheeth
12.1 Mechanism of Action
Natalizumab binds to the alpha4-subunit of alpha4 beta1 and alpha4 beta7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the alpha4-mediated adhesion of leukocytes to their counter-receptor(s). The receptors for the alpha4 family of integrins include vascular cell adhesion molecule-1 (VCAM-1), which is expressed on activated vascular endothelium, and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) present on vascular endothelial cells of the gastrointestinal tract. Disruption of these molecular interactions prevents transmigration of leukocytes across the endothelium into inflamed parenchymal tissue. In vitro, anti-alpha4-integrin antibodies also block alpha4-mediated cell binding to ligands such as osteopontin and an alternatively spliced domain of fibronectin, connecting segment-1 (CS-1). In vivo, natalizumab may further act to inhibit the interaction of alpha4 and on parenchymal cells, thereby inhibiting further recruitment and inflammatory activity of activated immune cells.
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