Artificial butter flavoring exacerbates Alzheimer's

A board to discuss various diet-centered approaches to treating or controlling Multiple Sclerosis, e.g., the Swank Diet

Artificial butter flavoring exacerbates Alzheimer's

Postby NHE » Tue Dec 18, 2012 5:01 am

The Butter Flavorant, Diacetyl, Exacerbates β-Amyloid Cytotoxicity
Chem. Res. Toxicol., 2012, 25 (10), pp 2083–2091

    Diacetyl (DA) [also known as 2,3-butadione], a ubiquitous butter-flavoring agent, was found to influence several aspects of amyloid-β (Aβ) aggregation—one of the two primary pathologies associated with Alzheimer's disease. Thioflavin T fluorescence and circular dichroism spectroscopic measurements revealed that DA accelerates Aβ1–42 aggregation into soluble and ultimately insoluble β-pleated sheet structures. DA was found to covalently bind to Arg5 of Aβ1–42 through proteolytic digestion–mass spectrometric experiments. These biophysical and chemical effects translated into the potentiation of Aβ1–42 cytotoxicity by DA toward SH-SY5Y cells in culture. DA easily traversed through a MDR1-MDCK cell monolayer, an in vitro model of the blood–brain barrier. Additionally, DA was found not only to be resistant to but also inhibitory toward glyoxalase I, the primary initiator of detoxification of amyloid-promoting reactive dicarbonyl species that are generated naturally in large amounts by neuronal tissue. In light of the chronic exposure of industry workers to DA, this study raises the troubling possibility of long-term neurological toxicity mediated by DA.
User avatar
NHE
Volunteer Moderator
 
Posts: 3300
Joined: Sat Nov 20, 2004 4:00 pm

Re: Artificial butter flavoring exacerbates Alzheimer's

Postby NHE » Wed Dec 19, 2012 4:10 pm

It seems that this stuff is widely used...

From the book "A Consumer's Dictionary of Food Additives" by Ruth Winter, M.S.
Also used as a carrier of berry, butter, buttermilk, butterscotch, caramel, chocolate, coffee, fruit, cheese, cherry, liquor, rum, wine, nut, almond spice, ginger ale, vanilla, and cream soda flavorings for beverages, ice cream, ices, candy, baked goods, gelatin desserts, chewing gum and shortening.
User avatar
NHE
Volunteer Moderator
 
Posts: 3300
Joined: Sat Nov 20, 2004 4:00 pm


Return to Diet

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service