thx for the heads up lc!
this info reminded me of a couple studies.. will need to get into their works cited when I can:
The possible role of gradual accumulation of copper, cadmium, lead and iron and gradual depletion of zinc, magnesium, selenium, vitamins B2, B6, D, and E and essential fatty acids in multiple sclerosishttp://www.ncbi.nlm.nih.gov/pubmed/10985916
"Vitamin B6 moderates intracellular nitric oxide (NO) production and extracellular Mg is required for NO release from the cell
, so that a deficiency of these nutrients results in increased NO production in the cell and reduced release from the cell. The trapped NO combines with superoxide to form peroxinitrite
, an extremely powerful free radical that leads to the myelin damage of MS
The multifaceted and widespread pathology of magnesium deficiencyhttp://www.ncbi.nlm.nih.gov/pubmed/11425281
"Even though Mg is by far the least abundant serum electrolyte, it is extremely important for the metabolism of Ca, K, P, Zn, Cu, Fe, Na, Pb, Cd, HCl, acetylcholine, and nitric oxide (NO),
for many enzymes, for the intracellular homeostasis and for activation of thiamine and therefore, for a very wide gamut of crucial body functions. ... The range of pathologies associated with Mg deficiency is staggering: hypertension (cardiovascular disease, kidney and liver damage, etc.), peroxynitrite
damage (migraine, multiple sclerosis, glaucoma, Alzheimer's disease, etc.), recurrent bacterial infection due to low levels of nitric oxide
in the cavities (sinuses, vagina, middle ear, lungs, throat, etc.), fungal infections due to a depressed immune system, thiamine deactivation (low gastric acid, behavioral disorders, etc.), premenstrual syndrome, Ca deficiency (osteoporosis, hypertension, mood swings, etc.), tooth cavities, hearing loss, diabetes type II, cramps, muscle weakness, impotence (lack of NO), aggression (lack of NO),
fibromas, K deficiency (arrhythmia, hypertension, some forms of cancer), Fe accumulation, etc..."
Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operationshttp://www.ncbi.nlm.nih.gov/pubmed/9564911
"Postoperative hypomagnesemia is common in patients who have undergone cardiac operations and is associated with clinically significant morbidity resulting from atrial and ventricular dysrhythmias. Magnesium supplementation may increase the cardiac index in the early postoperative period.
...Hypomagnesemia selectively impaired the release of nitric oxide
from the coronary endothelium. Because nitric oxide is a potent endogenous nitrovasodilator
and inhibitor of platelet aggregation and adhesion, hypomagnesemia could promote vasoconstriction and coronary thrombosis
in the early postoperative period."