Artificial sweeteners negatively impact gut microbiome

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Artificial sweeteners negatively impact gut microbiome

Postby NHE » Sat Nov 28, 2015 11:21 pm

Artificial sweeteners may promote diabetes, claim scientists.

Controversial research suggests artificial sweeteners may raise blood sugar levels by promoting growth of certain gut bacteria.

http://www.theguardian.com/science/2014 ... lood-sugar

In the first of a series of experiments, the Israeli group found that mice fed on three artificial sweeteners – saccharin, aspartame and sucralose – developed high blood sugar levels. But when the mice were given antibiotics to kill off their gut microbes, the ill effects disappeared.

The scientists then focused on saccharin. They transferred gut microbes from mice fed on the sweetener to different mice that had no gut bacteria of their own. Soon after, the recipient mice developed high blood sugar levels themselves. Genetic analyses of the gut microbes from mice fed on saccharin found that as a group they behaved differently, breaking down more carbohydrate in the diet than normal.

The scientists ran tests on 400 people and found that those who consumed the most artificial sweeteners had different gut microbes than others, and on average were heavier and more glucose intolerant.

In their final set of experiments, the scientists gave seven people the maximum allowed daily dose of saccharin for a week. Each dose was enough to sweeten around 40 cans of diet cola. At the end of the week, four in seven had high blood sugar levels and their gut microbes mirrored the changes seen in mice fed on the additives.

To round off the study, the researchers transferred bugs from the people who developed high blood sugar after massive doses of artificial sweeteners into mice that had no gut bugs of their own. These mice went on to develop high blood sugar too.
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Re: Artificial sweeteners negatively impact gut microbiome

Postby NHE » Sun Nov 29, 2015 3:58 am

Here's a link to the abstract and the data figures.

http://www.nature.com/nature/journal/v5 ... 13793.html


Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Nature. 514, 181–186. (09 October 2014)

    Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.
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