Study: Eval. Diet & Outcomes Progressive MS

A board to discuss various diet-centered approaches to treating or controlling Multiple Sclerosis, e.g., the Swank Diet

Study: Eval. Diet & Outcomes Progressive MS

Postby jimmylegs » Fri Sep 23, 2016 5:56 am

Evaluation of Dietary Nutrients in Relation to Clinical Outcomes in Chronic-Progressive Multiple Sclerosis
http://advances.nutrition.org/content/7/1/15A.short

"Objective: The purpose of this analysis is to determine which components of a modified Paleolithic diet are most related to patient outcomes as evaluated by the Medical Symptom Questionnaire (MSQ) in individuals with multiple sclerosis (MS) to identify nutrients related to outcomes.

Methods: This is a secondary analysis of nutrition data from a multimodal intervention which significantly reduced fatigue and improved physical functioning in subjects with MS. Data was obtained from FFQ, MSQ, exercise, and stress reduction data at baseline (pre-intervention) and 12 mo. The impact of min/d of exercise and stress reduction; intake of fiber, omega-3 fatty acids, calcium, iodine, potassium, retinol, and carotene; and vitamins B-1, B-2, B-3, B-5, B-6, B-9, B-12, K, C, A, and D on MSQ change were considered using bivariate and multiple regression models analyses. Interactions were considered with baseline, age, y with MS, and body mass index (BMI). All statistical analyses used SAS9.3.

Results: Variables that reached statistical of p≤ 0.1 were considered in the model. The final model included MSQ baseline, age*fiber, and fiber*baseline, and explained ∼83% in the variance of MSQ change. MSQ change is related to fiber, moderated by age and baseline. Plotting the data ( Figure 1) revealed in subjects aged <50 y that high fiber intake is strongly associated with improvement in MSQ. However, in subjects aged >60 y, high fiber did not prevent a decline in MSQ. Subjects with the poorest MSQ at baseline also benefited the most from higher fiber.

Conclusions: Our results indicate that improvement in MSQ is related to increased fiber intake, moderated by age and baseline MSQ. Recent discoveries in the microbiome on progression of MS may explain our results. Increased fiber intake alters the microbiome and may reduce inflammation or signal to the brain via pathways to improve MS symptoms."


hopefully one day someone finds the money/interest to also look at vit E and mag, zinc, copper, and iron, to also inquire re food prep and combos, to take serum values AND see how people are doing.

at least for now we can infer that magnesium status would better for those who saw benefit from high fibre
Effects of Dietary Fibers on Magnesium Absorption in Animals and Humans
http://jn.nutrition.org/content/133/1/1.full

we also know that improved mag means improved vit D3 status, independent of 'intake'. it would be nice to take another run at those FFQ results, look at a few other factors.
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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jimmylegs
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