2000 review: Dietary Factors Influencing Zinc Absorption

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2000 review: Dietary Factors Influencing Zinc Absorption

Postby jimmylegs » Wed Nov 07, 2018 11:18 am

Dietary Factors Influencing Zinc Absorption (2000)
https://academic.oup.com/jn/article/130/5/1378S/4686381

"ABSTRACT
Marginal zinc deficiency and suboptimal zinc status have been recognized in many groups of the population in both less developed and industrialized countries. Although the cause in some cases may be inadequate dietary intake of zinc, inhibitors of zinc absorption are most likely the most common causative factor.

Phytate, which is present in staple foods like cereals, corn and rice, has a strong negative effect on zinc absorption from composite meals. Inositol hexaphosphates and pentaphosphates are the phytate forms that exert these negative effects, whereas the lower phosphates have no or little effect on zinc absorption. The removal or reduction of phytate by enzyme (phytase) treatment, precipitation methods, germination, fermentation or plant breeding/genetic engineering markedly improves zinc absorption.

Iron can have a negative effect on zinc absorption, if given together in a supplement, whereas no effect is observed when the same amounts are present in a meal as fortificants.

Cadmium, which is increasing in the environment, also inhibits zinc absorption.

The amount of protein in a meal has a positive effect on zinc absorption, but individual proteins may act differently; e.g., casein has a modest inhibitory effect on zinc absorption compared with other protein sources.

Amino acids, such as histidine and methionine, and other low-molecular-weight ions, such as EDTA and organic acids (e.g., citrate), are known to have a positive effect on zinc absorption and have been used for zinc supplements. Knowledge about dietary factors that inhibit zinc absorption and about ways to overcome or remove these factors is essential when designing strategies to improve the zinc nutrition of vulnerable groups."
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Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Postby NHE » Thu Nov 08, 2018 2:34 am

jimmylegs wrote:Amino acids, such as histidine and methionine, and other low-molecular-weight ions, such as EDTA and organic acids (e.g., citrate), are known to have a positive effect on zinc absorption and have been used for zinc supplements.

EDTA is a chelator that readily binds divalent cations such as zinc, magnesium and calcium and increases their excretion. The study linked below found a 30x increase in the urinary excretion of zinc following EDTA treatment.

http://www.chelationmedicalcenter.com/! ... herapy.pdf
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Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Postby jimmylegs » Thu Nov 08, 2018 2:06 pm

without spending the time to dig, ('chelationmedicalcenter.com' is not my kind of resource for academia) i imagine the comparison may be apples and oranges; the quantities referred to in the separate cases not identical.
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Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Postby NHE » Fri Nov 09, 2018 3:11 am

jimmylegs wrote:without spending the time to dig, ('chelationmedicalcenter.com' is not my kind of resource for academia) i imagine the comparison may be apples and oranges; the quantities referred to in the separate cases not identical.

It's a link to a copy of a peer reviewed published paper. Did you even bother to click on the link? Even the paper you linked to raised several issues with EDTA.

Bo Lönnerdal, 2000 wrote:However, this positive effect is not always observed, and in some cases a negative effect on zinc absorption has been noted. It was realized that the ratio of EDTA to inhibitors such as phytate and other cations competing for complex formation, such as Ca2+, Mg2+ and Fe2+, was critical when it comes to the effect being positive or negative. It has subsequently been found that the Zn-EDTA complex is transported intact from the lumen into the enterocyte but not across the basolateral membrane (Hempe and Cousins 1989).

In effect, Zn-EDTA doesn' get into the bloodstream.

Bo Lönnerdal, 2000 wrote: The fact that no Zn-EDTA complex could be detected in plasma supported this notion and was further in agreement with findings by O'Dell (1969) that parenteral EDTA administration increases zinc excretion and that Zn-EDTA in blood is not utilizable.

Zn-EDTA is NOT utilizable!

Bo Lönnerdal, 2000 wrote:It is evident that the interaction between EDTA and zinc as well as other cations and other low-molecular-weight chelators (Desrosiers and Clydesdale, 1989) and its consequences for metal ion transport warrant further studies.

Yes, more study is needed! :idea: The paper cited did NOT even examine EDTA despite what the implications are of the use of the reference! :roll:
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Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Postby jimmylegs » Fri Nov 09, 2018 3:49 am

nope. no comment on quantities i guess?
take control of your own health
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Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Postby ElliotB » Fri Nov 09, 2018 3:22 pm

Happened to see this and thought it might be appropriate to add here. I never knew Zinc was so important:


Autism Linked to Zinc Deficiency in Childhood

https://www.newsweek.com/autism-linked- ... od-1209635
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Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Postby jimmylegs » Sat Nov 10, 2018 3:31 am

if interested, prasad is a go-to author for reading re zinc as an essential nutrient.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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