Green Tea

A board to discuss various diet-centered approaches to treating or controlling Multiple Sclerosis, e.g., the Swank Diet

Green Tea

Postby jackD » Mon Jul 05, 2010 9:55 pm

Green/White TEA can also help treat/cure a lot of your MS problems. It needs to be taken as a supplement to get the dosage at high levels and it is desirable that other things be taken along with it to be really effective.

It is all found in PubMed but it is very hard to find.

I still have a large mug of green/white tea about twice a day.

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novel therapeutic targets???

Postby jackD » Tue Jul 06, 2010 7:01 am

The abstract does not reveal what the hell they are talking about but the FULL text does. They did something right.

J
Neuroimmunol. 2007 Mar;184(1-2):17-26. Epub 2007 Jan 10.

Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets.

Aktas O, Waiczies S, Zipp F.

Institute for Neuroimmunology, Neuroscience Research Center, Charité -- Universitätsmedizin Berlin, Germany.

Abstract
Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central nervous system (CNS) and the major cause of neurological disability in young adults in Western countries.

In spite of intensive research efforts, treatment options established to date do not sufficiently prevent the accumulation of tissue damage and clinical disability in patients with MS.

We here describe recently identified molecules responsible for the inflammatory and the neurodegenerative processes in MS and its animal model, experimental autoimmune encephalomyelitis (EAE), and review new treatment options targeting both aspects of this disease.

PMID: 17222462 [PubMed - indexed for MEDLINE]


http://home.ix.netcom.com/~jdalton/egcg-neorond-ms.pdf

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Postby harry1 » Tue Jul 06, 2010 11:59 am

Thanks for the info here Jack !!

Question ... do you think that drinking Green Tea (bags) thru out the day is sufficient or should we take Green Tea Capsules ?? I used to drink Green Tea all day long as i love it however i quit a ways back as i was concerned after reading that it contains flouride which may not be good for us with demyelinating diseases.

Thanks !!

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Green/White GOOD for bones.

Postby jackD » Tue Jul 06, 2010 8:23 pm

The high flouride is not found in the teas commonly consumed in the western world. High flouride levels are found in "BRICK TEA" and is a low quality tea not generally exported.

Green Tea/White Tea actually helps bone strength as indicated in the below abstract.

jackD

Nutr Res. 2009 Jul;29(7):437-56.

Green tea and bone metabolism.

Shen CL, Yeh JK, Cao JJ, Wang JS.

Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430-9097, USA. leslie.shen@ttuhsc.edu

Erratum in:

Nutr Res. 2009 Sep;29(9):684.

Abstract
Osteoporosis is a major health problem in both elderly women and men. Epidemiological evidence has shown an association between tea consumption and the prevention of age-related bone loss in elderly women and men.

Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures.

This review describes the effect of green tea or its bioactive components on bone health, with an emphasis on (i) the prevalence and etiology of osteoporosis; (ii) the role of oxidative stress and antioxidants in osteoporosis; (iii) green tea composition and bioavailability; (iv) the effects of green tea and its active components on osteogenesis, osteoblastogenesis, and osteoclastogenesis from human epidemiological, animal, as well as cell culture studies; (v) possible mechanisms explaining the osteoprotective effects of green tea bioactive compounds; (vi) other bioactive components in tea that benefit bone health; and (vii) a summary and future direction of green tea and bone health research and the translational aspects.

In general, tea and its bioactive components might decrease the risk of fracture by improving bone mineral density and supporting osteoblastic activities while suppressing osteoclastic activities.

PMID: 19700031 [PubMed - indexed for MEDLINE]PMCID: PMC2754215
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5-6 cups 300+ mg EGCG

Postby jackD » Tue Jul 06, 2010 9:08 pm

I started taking green/white tear for the cardiovascular benefit. As stated below you need at least 5-6 cups per day for a total of about 300 mg of EGCG per day. I also dringk a mug of Green/White Tea (one tea bag of each) for an additional 300+ mg of mixed tea polyphenols.

I take a LifeExtension Decaffeinated Capsule daily which contains 325.25 mg of EGCG plus a mug of Green/White Tea each day.

Since more EGCG is better I will commonly take a second Green Tea Extract Capsule in the evening.

jackD

Am Coll Nutr. 2007 Aug;26(4):373S-388S.

Effects of green tea and EGCG on cardiovascular and metabolic health.
Wolfram S.

DSM Nutritional Products Ltd, Department of Human Nutrition and Health, P.O. Box 3255, Bldg. 241/425, CH-4002 Basel, Switzerland.

Abstract
Since ancient times green tea has been considered a health-promoting beverage. In recent years, scientists throughout the world have investigated the potential benefits of green tea and its most abundant catechin, epigallocatechin gallate (EGCG).

The anti-cancer effects of green tea and EGCG were the focus of early research, and encouraging data from in vitro, animal model, and human studies have emerged.

Due to the dominant role of cardiovascular disease and the dramatic rise of obesity and type 2 diabetes mellitus as major and interlinked healthcare problems, green tea and EGCG are increasingly being investigated in these areas.

Dose-response relationships observed in several epidemiological studies have indicated that pronounced cardiovascular and metabolic health benefits can be obtained by regular consumption of 5-6 or more cups of green tea per day.

Furthermore, intervention studies using similar amounts of green tea, containing 200-300 mg of EGCG, have demonstrated its usefulness for maintaining cardiovascular and metabolic health.

Additionally, there are numerous in vivo studies demonstrating that green tea and EGCG exert cardiovascular and metabolic benefits in these model systems. Therefore, green tea and EGCG can be regarded as food components useful for the maintenance of cardiovascular and metabolic health. To prove the effectiveness for disease prevention or treatment, several multi-center, long-term clinical studies investigating the effects of one precisely-defined green tea product on cardiovascular and metabolic endpoints would be necessary. The aim of this manuscript is to provide an overview of the research investigating the effects of green tea and green tea catechins on cardiovascular and metabolic health.

PMID: 17906191 [PubMed - indexed for MEDLINE]
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Green Tea's EGCG reduces MMP-9s

Postby jackD » Tue Jul 06, 2010 10:32 pm

MMP-9s are the thingies that make the hole in our BBB Blood Brain Barrier and enter our brain and eat our nerves myelin.

So reducing them a TAD is a great idea.

http://www.thisisms.com/ftopict-4186.html (More info on mmp-9s)

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Biochim Biophys Acta. 2000 Mar 16;1478(1):51-60.

Matrix metalloproteinase inhibition by green tea catechins.

Demeule M, Brossard M, Pagé M, Gingras D, Béliveau R.

Laboratoire de Médecine Moléculaire, Hopital Sainte-Justine - UQAM, C.P. 8888, Succursale centre-ville, Montréal, QC, Canada.

Abstract
We have investigated the effects of different biologically active components from natural products, including green tea polyphenols (GTP), resveratrol, genistein and organosulfur compounds from garlic, on matrix metalloproteinase (MMP)-2, MMP-9 and MMP-12 activities.

GTP caused the strongest inhibition of the three enzymes, as measured by fluorescence assays using gelatin or elastin as substrates.

The inhibition of MMP-2 and MMP-9 caused by GTP was confirmed by gelatin zymography and was observed for MMPs associated with both various rat tissues and human brain tumors (glioblastoma and pituitary tumors).

The activities of MMPs were also measured in the presence of various catechins isolated from green tea including (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate(ECG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC) and (+)-catechin (C).

The most potent inhibitors of these activities, as measured by fluorescence and by gelatin or casein zymography, were EGCG and ECG.

GTP and the different catechins had no effect on pancreatic elastase, suggesting that the effects of these molecules on MMP activities are specific.

Furthermore, in vitro activation of proMMP-2 secreted from the glioblastomas cell line U-87 by the lectin concanavalin A was completely inhibited by GTP and specifically by EGCG. These results indicate that catechins from green tea inhibit MMP activities and proMMP-2 activation.

PMID: 10719174 [PubMed - indexed for MEDLINE]
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Re: Green Tea

Postby NHE » Tue Jul 06, 2010 11:49 pm

harry1 wrote:Question ... do you think that drinking Green Tea (bags) thru out the day is sufficient or should we take Green Tea Capsules ?? I used to drink Green Tea all day long as i love it however i quit a ways back as i was concerned after reading that it contains fluoride which may not be good for us with demyelinating diseases.


We had a discussion a while back about green tea and fluoride. The thread links to an article from the Linus Pauling Institute which provides data on the fluoride content of some different teas. Their green tea sample came out at 0.3 mg/8 fl. ounces (237 mL).

http://www.thisisms.com/ftopicp-52182.html#52182

Here's some additional discussion of tea and fluoride. Ten to forty cups per day increases the risk for osteosclerosis.

http://www.thisisms.com/ftopicp-34250.html#34250

Lastly, the following article demonstrated that tea fluoride varies inversely with the quality of the tea as Jack indicated. The better the tea, the lower the fluoride.

http://www.thisisms.com/ftopicp-34250.html#34250


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White Tea?

Postby jackD » Wed Jul 07, 2010 12:24 am

White Tea has much less fluorides and LOTS OF FLAVONOIDS-- 195 mg per cup. Most of it is EGCG.

I like a little color and a stronger flavor so I dip in a green tea bag for a short period of time.

One could drink over a liter of GOOD green tea with no problems from excess flourides. However my bladder and my social life could not handle this quantity.

The ideal quantity of green tea would be 10 cups. That is why you need to get most of the EGCG from GREEN TEA EXTRACTS.

I enjoy my white tea with some green tea especially with an extra 200 mg of l-theanine added.

jackD

PMID: 12499631 [PubMed - indexed for MEDLINE]

Biol Pharm Bull. 2002 Dec;25(12):1513-8.

Neuroprotective effects of the green tea components theanine and catechins.

Kakuda T.

Central Research Institute, Itoen, Ltd, Shuzuoka, Japan.

Abstract
The neuroprotective effects of theanine and catechins contained in green tea are discussed.

Although the death of cultured rat cortical neurons was induced by the application of glutamic acid, this neuronal death was suppressed with exposure to theanine.

The death of hippocampal CA1 pyramidal neurons caused by transient forebrain ischemia in the gerbil was inhibited with the ventricular preadministration of theanine.

The neuronal death of the hippocampal CA3 region by kainate was also prevented by the administration of theanine. Theanine has a higher binding capacity for the AMPA/kainate receptors than for NMDA receptors, although the binding capacity in all cases is markedly less than that of glutamic acid.

The results of the present study suggest that the mechanism of the neuroprotective effect of theanine is related not only to the glutamate receptor but also to other mechanisms such as the glutamate transporter, although further studies are needed.

One of the onset mechanisms for arteriosclerosis, a major factor in ischemic cerebrovascular disease, is probably the oxidative alteration of low-density lipoprotein (LDL) by active oxygen species. The oxidative alterations of LDL were shown to be prevented by tea catechins. Scavenging of *O(2)(-) was also exhibited by tea catechins.

The neuroprotective effects of theanine and catechins contained in green tea are a focus of considerable attention, and further studies are warranted.
PMID: 12499631 [PubMed - indexed for MEDLINE]
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Postby harry1 » Wed Jul 07, 2010 7:04 am

Lots of great info again JackD and NHE !!!

Few thoughts ... so how do we know if it's a ''Brick'' tea? Is the tea sold at the grocery store i.e. Salada brand o.k. or other possibly other brands sold at Vitacost as it seems that most come from China?? Secondly maybe i should just drink White Tea instead and also any thoughts about Japanese Teas? Lastly they do sell ECGC capsules at Vitacost and so do you think they would work as well as Green Tea bags or Green Tea Extract?

Thanks again guys as it's interesting !!!

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Postby jackD » Fri Jul 09, 2010 3:53 am

Brick Tea is of such low quality that it is sold literally in massive chunks in the shape/size of a small brick.

I would not worry about finding it in any tea bags sold in most stores.

Drinking white tea would be ideal. I would recommend Salada 100% Pure White Tea made from White Tea Buds. There are other kinds of white tea (i.e needles) but I have not researched that. I know nothing about Japanese Teas.

I also recommend Life Extensions MEGA GREEN TEA EXTRACT it has 98%polyphenols (710.g mg) and 45% is EGCG (326.25 mg).

So have one green tea caspsule with the above content and enjoy some white tea as a nice beverage.

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green tea -prevention -TNFa

Postby jackD » Fri Jul 09, 2010 3:04 pm

Here is where I got the idea that "10 cups of tea is the ideal".

jackD

p.s. I prefer the Green Tea Extract capsules plus a large mug of green white tea.


Ann N Y Acad Sci. 2001 Apr;928:274-80.

A new function of green tea: prevention of lifestyle-related diseases.

Sueoka N, Suganuma M, Sueoka E, Okabe S, Matsuyama S, Imai K, Nakachi K, Fujiki H.

Saitama Cancer Center Research Institute, Japan.

Abstract
In the normal human life span, there occur lifestyle-related diseases that may be preventable with nontoxic agents.

This paper deals with the preventive activity of green tea in some lifestyle-related diseases.

Green tea is one of the most practical cancer preventives, as we have shown in various in vitro and in vivo experiments, along with epidemiological studies.

Among various biological effects of green tea, we have focused on its inhibitory effect on TNF-alpha gene expression mediated through inhibition of NF-kappaB and AP-1 activation.

Based on our recent results with TNF-alpha-deficient mice, TNF-alpha is an endogenous tumor promoter. TNF-alpha is also known to be a central mediator in chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis.

We therefore hypothesized that green tea might be a preventive agent for chronic inflammatory diseases.

To test this hypothesis, TNF-alpha transgenic mice, which overexpress TNF-alpha only in the lungs, were examined. The TNF-alpha transgenic mouse is an animal model of human idiopathic pulmonary fibrosis which also frequently develops lung cancer.

Expressions of TNF-alpha and IL-6 were inhibited in the lungs of these mice after treatment with green tea in drinking water for 4 months. In addition, judging from the results of a prospective cohort study in Saitama Prefecture, Japan, green tea helps to prevent cardiovascular disease.

In this study, a decreased relative risk of death from cardiovascular disease was found for people consuming over 10 cups of green tea a day, and green tea also had life-prolonging effects on cumulative survival.

These data suggest that green tea has preventive effects on both chronic inflammatory diseases and lifestyle-related diseases (including cardiovascular disease and cancer), resulting in prolongation of life span.

PMID: 11795518 [PubMed - indexed for MEDLINE]
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Green tea and efedra

Postby tejana971 » Tue Sep 07, 2010 9:14 am

Hi everyone! I'm allergic to efedra so does that mean green tea is out for me? NERVOUS!!!!

Thanks alot!
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