gkalman wrote:I would guess that they had different criteria for study participants. For example if one study required one relapse within two years, while the other required two relapses within one year, one would expect placebo groups (as well as other groups) to be very different.
gkalman wrote:Oops, per your last question, I am not able to see the third study (I don't have a subscription). But, I thought that Betaferon was only very marginally helpful. I looked into it some years ago, so I don't remember all the details. However, the lack of effectiveness is one of the main reasons my wife decided to do studies as opposed to going on approved medication.
1.FINGOLIMOD 2.Interferon Beta
1a)1.25mg(N=420) 1b)0.5mg(N=429) 2a)(N=431)
Annualized relapse rate(primary end point) - no. (95%CI)
1a)0.20(0.16 to 0.26) 1b)0.16(0.12 to 0.21) 2a)0.33(0.21 to 0.42)
Patients with no confirmed relapse %(CI95%)
1a)79.8(75.9 to 83.7) 1b)82.6(79.0 to 86.3) 2a)69.3(64.8 to 73.
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