Laquinimod is supposedly in the early stages of a Phase III trial right now, although the article below is the latest thing I can find about it's status and it says they are still conducting additional Phase II studies. All this to say that it is probably at least 3 years away from being available to anybody other than trial participants...or are you considering participating in a trial?
Teva and Active Biotech Announce That Laquinimod Phase II Data Has Been Published Today in Neurology
BUSINESS WIRE - March 22, 2005 - Teva Pharmaceutical Industries and Active Biotech announced today that the final report of the Phase II study of laquinimod, which was successfully concluded in September 2003, has been published today in NEUROLOGY:
"Treatment with laquinimod reduces development of active MRI lesions in relapsing MS" by C. Polman, F. Barkhof, M. Sandberg-Wollheim, A. Linde, O. Nordle and T. Nederman". Neurology 2005; vol.64, No.6 p. 987.
Laquinimod is a novel immunomodulatory substance developed by Active Biotech. It has the potential to be the first orally-available disease modifying treatment for multiple sclerosis (MS).
In June 2004, Teva and Active Biotech signed an agreement for the future global development and commercialization of laquinimod.
The objective of the concluded Phase II study was to evaluate, in relapsing MS patients, the efficacy of 2 doses of laquinimod compared to placebo, based on its ability to suppress the development of active MRI lesions, as well as its safety and tolerability. It was concluded that daily treatment with laquinimod at a dose of 0.3 mg, reduced the mean cumulative number of active lesions by 44% compared to placebo (p less than 0.05) Its safety profile was very favorable; there were no clinical signs of undesired inflammatory manifestations.
Currently, additional Phase II studies are ongoing, aimed at evaluating the benefit of higher doses of laquinimod.
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