Dr. Christian Confavreux in Lyon and Dr. Etienne-Emile Baulieu in Paris are getting close to launching a placebo-controlled trial of progestin – a derivative of the sex hormone progesterone – involving 300 post-partum women with MS (for the rationale of this experiment please refer to our preceding reports). Enrollment will be open to patients in those European countries where there are centers that participate in the European Database for Multiple Sclerosis (EDMUS), a cooperative network of MS clinicians headed by Dr. Confavreux.
The POPART’MUS study aim is then to compare MS clinical activity, in terms of relapses during the post-partum period, in women treated immediately after delivery and for 3 months with progestin and estradiol, by comparison to placebo-treated women.
If a beneficial effect of progestin drugs on relapses could be demonstrated, it would provide a new, rapidly active, safe and cheap preventive treatment for post-partum relapses.
Three hundred women will be enrolled in the POPART’MUS study, which will start during late spring 2005. Results are expected to be available in 2008.
Would you mind telling us something about yourself.
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