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L
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PostPosted: Sun Jul 25, 2010 6:25 pm 
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dignan wrote:
I added BIIB033 (Anti-Lingo) to the phase 1 list based on a post from ElMarino. The post cites a Dow Jones article. The trial is also now listed in clinicaltrials.gov

http://english.capital.gr/news.asp?id=896271

http://www.clinicaltrials.gov/ct2/show/NCT01052506


ElMarino! That was me! When I was briefly hiding from someone who was sending me odd PMs. I got tired of the silly name and went back to plain old 'L'.. They were an NHS employee no less, who I new in real life, pretending to be a patient. Seriously!
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ssrn00
 Post subject: Drug Pipeline
PostPosted: Wed Aug 25, 2010 8:11 am 
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:wink: Thank you for the composite of available treatment options for MS, I have been attempting to find an alternattive treatment this will definitely help. I am new to this site is there anyway I can SHARE this? ThankYou, Sharon
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dignan
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PostPosted: Thu Aug 26, 2010 1:32 pm 
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ssrn00, there is a "Natural Approach" forum that might be appropriate for your experience. If you're not sure about the rules of the board, they can be found here: http://www.thisisms.com/ftopict-39.html
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dignan
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PostPosted: Sat Sep 18, 2010 9:46 am 
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Based on a posting from squiffy2 I added MIS416 to the phase 2 list. I like it because it's for progressive MS and Innate Therapeutics got some funding from Fast Forward:

<shortened url>
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Daisy3
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PostPosted: Sat Sep 18, 2010 10:47 am 
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I had a brief e-mail conversation with someone from Innatetherapeutics and the drug is still a good 5/6 years off.

Frustrating.
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NHE
 Post subject: Re: MIS416
PostPosted: Sat Sep 18, 2010 4:34 pm 
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The link to the Innate Therapeutics pdf didn't work. I found this article instead.

http://www.scoop.co.nz/stories/GE1009/S ... atment.htm

NHE
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dignan
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PostPosted: Sat Sep 18, 2010 6:29 pm 
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Thanks NHE, don't know what happened to that link. Daisy, yep, it's a drag. Actually, anything that's still in phase 2, even if it has been in phase 2 trials for a couple of years, is AT LEAST 4 years from approval, and 5 or 6 years is more realistic, and 8 years isn't unreasonable. Clinical trials take a long time, what with setting them up, recruiting, collection and analysis of results, regulatory filings etc.
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dignan
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PostPosted: Wed Sep 22, 2010 9:09 am 
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Based on this post from gkalman, I added gilenya to the approved list:

http://www.thisisms.com/ftopict-13876.html

I think we are going to see new MS drug approvals every year from now on (until a cure).
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CureOrBust
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PostPosted: Thu Sep 23, 2010 4:02 am 
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Quote:
Elimination of a Hydroxyl Group in FTY720 Dramatically Improves the Phosphorylation Rate
...Our results suggest that AAL(R) is a better tool than FTY720 for in vivo studies with S1P analogs and would probably be a more effective immunosuppressant than FTY720...

http://molpharm.aspetjournals.org/content/78/4/685.abstract
Maybe this will one day reach the pipeline, if that cure dignan talks about doesn't come first.
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dignan
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PostPosted: Thu Oct 28, 2010 4:14 pm 
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I moved Amiloride from phase 1 to phase 2 (and it's a primary progressive trial!) based on this:


Quote:
The primary objective of the study is to evaluate the effects of the drug, oral amiloride in primary progressive Multiple Sclerosis (MS) patients during 12 months of treatment. This project aims to evaluate the effect of oral amiloride using Magnetic resonance imaging (brain scans).

Participants will be drawn from those who previously completed the one year MRI study on primary progressive MS patients on specific treatment. Participants from that study will continue on to this present study. Participants will be given oral amiloride at a dose of 10mg a day daily for a period of 52 weeks.

All participants will be followed up for one year, undergoing 4 MRI scans. The participants will attend clinic visits at the same time for clinical outcomes and have 20ml of blood collected and urine sample at each visit.


http://nres.npsa.nhs.uk/researchsummari ... 75297&p=38
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Lyon
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PostPosted: Thu Oct 28, 2010 4:37 pm 
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Last edited by Lyon on Sun Nov 20, 2011 5:34 pm, edited 1 time in total.

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indigoinmotion
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PostPosted: Fri Oct 29, 2010 12:55 pm 
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yes, great job, thanks bunches!!
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dignan
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PostPosted: Sat Oct 30, 2010 11:20 am 
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Well, I just finished going through the phase 1 list and removed a few things. There are only 14 substances in phase 1 now. Hopefully there is a lot out there that I am missing...
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dignan
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PostPosted: Sun Nov 07, 2010 2:21 pm 
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I added a PPMS trial of Ocrelizumab to the phase 3 list, based on this clinicaltrials.gov listing.

On the one hand, this is GREAT news! Any time a new substance enters phase 3 it's a major step in the right direction. Just as importantly, it is being tested for PPMS, where the need is greatest.

On the other hand, this drug has a bit of a black cloud over it as there was a treatment-related death in the most recent phase 2 MS trial and it was discontinued as an experimental treatment for RA earlier this year due to side-effect concerns.

It's never straight forward when it comes to treating this disease, is it?
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dignan
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PostPosted: Tue Mar 08, 2011 7:05 pm 
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I added a few things to the phase 1 and 2 lists. See here for the blow-by-blow.
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Board index » Multiple Sclerosis » Drug Pipeline

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