This is my first post and I don't really have a clue what I am doing! I came across this "lead-in" article on the "news for the day", i.e., current, New England Journal website. It costs $29.95 to read the entire article and I really don't want to make the investment. Perhaps some of you know what this means:
Progressive Multifocal Leukoencephalopathy, Natalizumab, and Multiple Sclerosis
To the Editor: According to the established definition of multiple sclerosis, the condition in the patient described by Kleinschmidt-DeMasters and Tyler (July 28 issue) should not have been diagnosed as multiple sclerosis. Apart from the unusual clinical findings, no oligoclonal bands were detected in two separate examinations of the cerebrospinal fluid, and repeated magnetic resonance imaging (MRI) scans obtained over the course of several years showed new and enlarging, but never enhancing, lesions. The most convincing argument against a diagnosis of multiple sclerosis is the neuropathology: no lesions that are characteristic for multiple sclerosis were detected. The patient . . . [Full Text of this Article]
Are they saying that this patient who took Natalizumab and developed PML didn't have MS?????? Any info or thoughts?