Here's some info on the therapeutic action(s) of cannabinoids in MS.
Therapeutic Action of Cannabinoid on Axonal Injury
This study examined whether the potent cannabinoid HU210 ameliorates axonal injury through its indirect action to stimulate the secretion of corticosterone.....
the ameliorating effects of cannabinoids on axonal injury associated with multiple sclerosis are achieved by its direct action, but not by its indirect action to elevate the serum corticosterone levels.
It's interesting to me that the apparent indirect action of cannabinoids to elevate the anti-inflammatory hormone corticosterone was not responsible for the beneficial effects of cannabinoids in protecting axons.
Here's another one. The abstract itself is way beyond anything I could possibly understand but the conclusion is interesting. I apologize if it's already been posted. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic-and antidepressant-like effects
chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.
And yet another interesting one from 2002 I don't understand either beyond the title/conclusion. Cannabinoids promote oligodendrocyte progenitor survival
These data identify oligodendrocytes as potential targets of cannabinoid action in the CNS.
And, lastly another abstract that I think (no guarantees on my interpretations of these things) suggests that Ultra-low dose naltrexone enhances cannabinoids...
anti-pain properties and improvements in motor functioning.
These data suggest a mechanism of cannabinoid-opioid interaction whereby activated opioid receptors that couple to Gs-proteins may attenuate cannabinoid-induced antinociception and/or motor functioning.
So, at least in rats, there's some info to suggest that cannabinoids may have a role in protecting axons, in generating new neurons in the hippocampus that may account for its antidepressant-like effects, for promoting the survival of cells (oligodendrocytes) important to myelin, and for working together with LDN to counteract pain and/or to improve motor functioning.
Does anyone know if this "HU210" is the same as the Sativex that's been approved in Canada and the UK for MS?