Hype? Rituximab : Drug Pipeline

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Hype? Rituximab

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bromley

Post subject: Hype? Rituximab

Posted: Sat Jan 28, 2006 2:36 pm

Family Elder

Joined: Fri Sep 10, 2004 3:00 pm
Posts: 1889

As we all know there are multitudes of drugs in trial.

Rituximab is being trialled with RR, SP and PP sufferers. Although other threads have discussed the possibility of MS being one disease with the immune system response / or not, differentiating between the various types.

The media coverage of Rituximab has been very upbeat as illustrated below:

"In patients who have been treated with rituximab and haven't responded to other treatments, Dr. Stuve says, "The response to the Rituxan was really dramatic, in terms of not only stopping disease progression but really helping the patients recover some of the neurological function that they had lost in previous month and years"."

I'm always wary of such hype but when a medic claims that the drug stops progression this is a big claim.

My questions:

Has anyone received Rituximab? Or know someone who has received it?

If it did prove good, what fast-tracking is permissible given that it is already in use for other conditions?

Thanks

Ian

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Damjan

Post subject:

Posted: Sun Jan 29, 2006 8:09 am

Getting to Know You...

Joined: Fri Apr 08, 2005 3:00 pm
Posts: 15
Location: Slovenia, Europe

Anybody noticed safety warnings on Rituxan homepage?

Quote:

Important Safety Information

WARNINGS

Fatal Infusion Reactions: Deaths within 24 hours of RITUXAN infusion have been reported. These fatal reactions followed an infusion reaction complex which included hypoxia, pulmonary infiltrates, acute respiratory distress syndrome, myocardial infarction, ventricular fibrillation or cardiogenic shock. Approximately 80% of fatal infusion reactions occurred in association with the first infusion. (See WARNINGS and ADVERSE REACTIONS in full Prescribing Information.)

Patients who develop severe infusion reactions should have RITUXAN infusion discontinued and receive medical treatment.

Tumor Lysis Syndrome (TLS): Acute renal failure requiring dialysis with instances of fatal outcome has been reported in the setting of TLS following treatment with RITUXAN. (See WARNINGS in full Prescribing Information.)

Severe Mucocutaneous Reactions: Severe mucocutaneous reactions, some with fatal outcome, have been reported in association with RITUXAN treatment. (See WARNINGS and ADVERSE REACTIONS in full Prescribing Information.)

http://www.rituxan.com/

Best regards,
Damjan

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flipflopper

Post subject:

Posted: Sun Jan 29, 2006 4:04 pm

Family Elder

Joined: Wed Nov 09, 2005 4:00 pm
Posts: 183

I erased my post because the answer to the question I asked is now obvious to me

Last edited by flipflopper on Sat May 26, 2007 3:04 pm, edited 1 time in total.

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bromley

Post subject:

Posted: Thu Feb 02, 2006 1:26 am

Family Elder

Joined: Fri Sep 10, 2004 3:00 pm
Posts: 1889

Dear all,

Given the good results reported from the use of Rituximab, I e-mailed one of the neuros I had seen (one of the top MS neuros in the UK) to find out if Rituximab was likely to be effective. His response:

"Rituximab is currently in two phase III studies (PP and RRMS) and is very promising – it will also tell us how important B cells are in the pathogenesis of MS".

Just his opinion of course, but I've become wary of the hype surrounding many treatments on trial. Fingers crossed that we might have another effective treatement in a few years and that the trials will provide more in-sights into ths complex disease.

Ian

PS And it wasn't only the good results reported in the press. I also posted two examples (from the BCP site) where Rituximab had helped in really grim MS cases.

http://www.bostoncure.org:8080/article. ... =nocomment

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