I was on Tecfidera for 3 weeks. They were excellent! No flushing, except maybe a mild flush one morning I had a little on my face but nothing significant. I had some itching on my arms one morning.
I had been on Copaxone for 10 years with significant injection site reactions and severe nausea and vomiting that no one realized was due to the Copaxone. Only a small number of people have GI symptoms on Copaxone. So I walked around vomiting for almost 10 years not knowing why everyone telling me maybe it was my migraines, or just a sensitive stomach!
I was thrilled to try this new "oral" drug. I did fine at the lower dose. It wasn't till I went up to the higher dose I developed severe abdominal pain, could not eat anything. I thought I had the flu. Little vomiting, no diarrhea. I ended up in the hospital dehydrated with low blood pressure. The hospitalist thinks I do have a very sensitive GI tract.
I don't think I'll get to rechallenge it. The reaction was pretty severe. I am told this is a very unusual reaction. Most of the GI symptoms are more mild and transient. I am sure this is true. But there are outliers in every situation. But it is important to realize that more severe reactions can occur. I am so disappointed because I really wanted to take this drug! But we'll see. I doubt I can try again. Good luck to you all.