Sorry for the slow reply.........I have never tried Milk Thistle, although it does interest me somewhat and I would be interested to here what others think about it. I have always been somewhat leery of overloading the liver with supplements, especially while taking something like Aubagio which does impact the liver. This is why they monitor liver function.
I never had any depression issues that I would attribute to the Aubagio. I have been depressed a few times, like when I suffer an MS relapse. But that subsides as the attack subsides, and I figure most folks would feel the same. I personally do not desire to take another pill unless it is absolutely necessary. It also helps to have someone close enough to you to monitor for depression. My spouse and I have discussed this issue previously, about a year after diagnosis, so that they can kinda monitor me for that. Depression is one of those things that can sneak up on someone, and the person not realize it. But the answer to your question is no, Aubagio did not cause depression for me.
As far as alcohol, I have always been a casual drinker. Although I have almost quit now, as I have not had a drink this year. I do still drink at times, but just feel that it is not in my best overall health interest to do so very often. As mentioned above, the liver function is impacted by many of these DMD's and continuing to cause it to work even harder with the alcohol can't be in our best interest. When I do drink, I have learned to enjoy a bit of wine. I mean hey, at least there are some health benefits to a good glass of red wine..........
I have gone off the Aubagio officially after almost a year and a half. I am about to start Rebif at the advice of my Neuro. I will miss the Aubagio for it's ease of dosing and few side effects. I am also very apprehensive about the rebif for all of it's side effects and will not give it very long if it makes me feel worse. I wish I had better luck with the Aubagio, but feel it is worth a shot for many as it has worked for some and offers a much higher degree of tolerability than many of the others.