Redhill announces Phase IIa trial data

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Redhill announces Phase IIa trial data

Postby MSUK » Fri Apr 01, 2016 2:32 am

RedHill Biopharma has announced “encouraging” top-line interim results from its CEASE-MS Phase IIa proof-of-concept (PoC) clinical study evaluating fixed oral doses of RHB-104 in patients treated for relapsing-remitting multiple sclerosis (RRMS)....Read more - http://www.ms-uk.org/MSnews
MS-UK - http://www.ms-uk.org/
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Re: Redhill announces Phase IIa trial data

Postby CureOrBust » Sat Apr 02, 2016 5:33 pm

Does anyone know what/which antibiotics are in this pill?
RHB-104 is a proprietary and potentially groundbreaking antibiotic combination therapy in oral capsule formulation, with potent intracellular, antimycobacterial and anti-inflammatory properties.
The quote implies the individual components are out of patent, and hence the "proprietary ... antibiotic combination". For example, i *think* doxycycline in itself is both an antibiotic and anti-inflammatory. I would like to know which antibiotics are actually used, not necessarily the proprietary proportions.
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Re: Redhill announces Phase IIa trial data

Postby NHE » Sat Apr 02, 2016 8:17 pm

CureOrBust wrote:Does anyone know what/which antibiotics are in this pill?

RHB-104 is also being trialed for Crohn's Disease.
http://www.redhillbio.com/pipeline-overview

Here's a statement from their Crohn's Disease patent.
http://patft.uspto.gov/netacgi/nph-Pars ... PN/9072763

A method to treat inflammatory bowel disease comprising:
providing a solid oral dosage form comprising:
rifabutin;
clarithromycin;
clofazimine; and
polyethylene glycol,
wherein the polyethylene glycol (i) has an average molecular weight of between 1000-15000 Daltons, and (ii) is between 300% and 700% w/w relative to the amount of clofazimine; and
administering, to a patient, the solid oral dosage form.
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Re: Redhill announces Phase IIa trial data

Postby NHE » Mon Apr 04, 2016 11:35 pm

NHE wrote:Here's a statement from their Crohn's Disease patent.
http://patft.uspto.gov/netacgi/nph-Pars ... PN/9072763

A method to treat inflammatory bowel disease comprising:
providing a solid oral dosage form comprising:
rifabutin;
clarithromycin;
clofazimine; and
polyethylene glycol,
wherein the polyethylene glycol (i) has an average molecular weight of between 1000-15000 Daltons, and (ii) is between 300% and 700% w/w relative to the amount of clofazimine; and
administering, to a patient, the solid oral dosage form.


None of these 3 drugs sound like much fun.

Rifabutin
    "Rifabutin will cause your urine, stools, saliva, skin, sputum, sweat, and tears to turn reddish-orange to brown-orange. This is to be expected while you are taking this medicine. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. It is best not to wear soft contact lenses while taking this medicine. Hard contact lenses are not discolored by rifabutin.

    Birth control pills may not work properly if you take them while you are taking rifabutin. Unplanned pregnancies may occur. Use a different means of birth control while you are taking rifabutin. If you have any questions about this, check with your doctor."

Clarithromycin
    "This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop using this medicine and call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat while you or your child are using this medicine.

    Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you or your child are using this medicine. "

Clofazimine
    "Clofazimine may cause pink or red to brownish-black discoloration of the skin within a few weeks after you start taking it. Because of the skin discoloration, some patients may become depressed. The discoloration will go away when you stop taking this medicine. However, it may take several months or years for the skin to clear up completely. If skin discoloration causes you to feel very depressed or to have thoughts of suicide, check with your doctor immediately.

    Clofazimine commonly causes discoloration of the feces, lining of the eyelids, sputum, sweat, tears, and urine. Usually this side effect does not require medical attention, but the discoloration may not go away. However, clofazimine may also cause bloody or black, tarry stools. This side effect may be a symptom of serious bleeding problems that do require medical attention."
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