MLN0415

A board to discuss future MS therapies in early stage (Phase I or II) trials.

MLN0415

Postby bromley » Wed Aug 30, 2006 6:41 am

Dignan,

This is on your list as Phase I but there is a lot of coverage in the media today.

Ian

http://c.moreover.com/click/here.pl?j625859514&w=464753
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Postby bromley » Wed Aug 30, 2006 11:40 am

Another article on the same story. At least a large drugs company is also involved which should help fund the trials. Many of the drugs in trial e.g. Rituxan (and this one) are targetting both MS and RA. I wonder if any poor soul has got both?

Ian

Millennium launches test for inflammation treatment

Millennium Pharmaceuticals Inc. has launched an early-stage human clinical trial to test a new treatment for inflammation.

The Cambridge, Mass. based company announced Wednesday that it had launched the Phase I trial of MLN0415, a molecule Millennium's scientists have discovered that apparently targets a key pathway involved in inflammation. The thought is that the drug could help prevent inflammation or delay the progression of an inflammation-related disease.

The trial will involve up to 72 volunteers and assess safety and tolerability of the drug. If successful, the drug will move into Phase II trials involving actual sick patients and then a larger pool of sick patients in Phase III trials before it is submitted for federal marketing approval.

Millennium is developing the drug with global pharmaceutical company Sanofi-Aventis; the two formed an alliance to develop and market new drugs focused on inflammatory diseases such as rheumatoid arthritis and multiple sclerosis.

Source: Yahoo Finance Copyright © 2006 Yahoo! Inc. All rights reserved
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Postby Toyoterry » Wed Aug 30, 2006 12:17 pm

My wife has RA and I have MS. I hope they come up with something better before our kids get older. The genes are not on their side.
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