I'm not very scientific but I did read that Calpain is a mediator of myelin breakdown so maybe this will be a promising avenue for research.
A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis.Hassen GW, Feliberti J, Kesner L, Stracher A, Mokhtarian F.
SUNY Downstate Medical Center, USA.
Aberrant activation of calpain plays a key role in the pathophysiology of several neurodegenerative disorders. Calpain is increasingly expressed in inflammatory cells in EAE and is significantly elevated in the white matter of patients with multiple sclerosis, thus calpain inhibition could be a target for therapeutic intervention. The experiments reported here employed a myelin oligodendrocyte glycoprotein-induced disease model in C57Bl/6 mice (EAE) and a novel calpain inhibitor, targeted to nervous tissue. CYLA was found to reduce clinical signs of EAE and prevent demyelination and inflammatory infiltration in a dose- and time-dependent manner. Oral administration of the diacetal prodrug was equally effective.
PMID: 17007940 [PubMed - as supplied by publisher]