Fantastic MS research summary

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Fantastic MS research summary

Postby dignan » Wed Jan 17, 2007 11:08 pm

This might be my favorite research summary of all time. Nice, brief overview of MS at the beginning, followed by a description of every experimental treatment type and all the representative clinical trials for each type of treatment. A lot to absorb, but worth the effort I think.



http://www.sven-meuth.de/Files/pdf/P15.pdf

Immunotherapeutic Approaches in MS: Update on Pathophysiology and
Emerging Agents or Strategies 2006


Endocrine, Metabolic & Immune Disorders - Drug Targets, 2007, Bentham Science Publishers Ltd.
C. Kleinschnitz1, S.G. Meuth1, B.C. Kieseier2 and H. Wiendl1,*
Departments of Neurology, 1Bayerische Julius-Maximilians-Universität Würzburg, Germany and 2Heinrich-Heine-
Universität Düsseldorf, Germany
User avatar
dignan
Family Elder
 
Posts: 1608
Joined: Wed Aug 11, 2004 3:00 pm

Advertisement

WOW

Postby gwa » Thu Jan 18, 2007 10:02 am

Thanks Dignan,

What a treasure trove of information!


8O 8O

gwa
User avatar
gwa
Family Elder
 
Posts: 846
Joined: Thu Dec 01, 2005 4:00 pm

Postby mjs » Thu Jan 18, 2007 4:29 pm

Wow, definintely a great article.

The stuff on monoclonal antibodies (eg, Tysabri) is sobering, and the warnings about FTY720 are not fun to read. I've been hopeful about FTY because it allegedly does not act as a general immunosuppresant, but apparently it affects the bone marrow and may also cause the PML (and god knows what else) (see p13).

It makes you wonder about all immunosuppresants really, and what the long term affects could be.

Still, I was encouraged by the positive write-up about omega-3 fatty acids - I'm a big believer in these (would encourage anybody to read the Jelinek book - it's his take on the Swank diet).

And T-cell vaccination is also promising - I'm watching the Tovaxin stuff closely - fingers crossed!
User avatar
mjs
Family Member
 
Posts: 42
Joined: Wed Jan 17, 2007 4:00 pm

Postby flipflopper » Thu Jan 18, 2007 6:35 pm

I love this research summary. Thanks a lot for the link Dignan!
User avatar
flipflopper
Family Elder
 
Posts: 183
Joined: Wed Nov 09, 2005 4:00 pm

Postby marcstck » Thu Jan 18, 2007 7:55 pm

Is anybody else having trouble with this link? When I click on it, it freezes my browser, and when I download the file to my desktop Acrobat says that the file can't be opened.

I really wanted to read this, it sounds quite interesting...
User avatar
marcstck
Family Elder
 
Posts: 560
Joined: Tue Jan 03, 2006 4:00 pm

Postby gwa » Thu Jan 18, 2007 8:03 pm

I had no trouble downloading it , but the first time I only got about 12 pages read and my computer froze.

After rebooting, I was able to read the whole thing. There must be a bug or something in it.

gwa
User avatar
gwa
Family Elder
 
Posts: 846
Joined: Thu Dec 01, 2005 4:00 pm

Postby mjs » Thu Jan 18, 2007 10:22 pm

Try right-clicking and selecting 'save as'.
User avatar
mjs
Family Member
 
Posts: 42
Joined: Wed Jan 17, 2007 4:00 pm

Postby Arron » Sun Jan 21, 2007 2:08 am

nice find!
Disclaimer: Any information you find on this site should not be considered medical advice. All decisions should be made with the consent of your doctor, otherwise you are at your own risk.
User avatar
Arron
Volunteer Moderator
 
Posts: 892
Joined: Sun Feb 01, 2004 4:00 pm
Location: California, USA

Postby Lyon » Wed Jan 24, 2007 6:10 pm

Interesting file dignan, Thanks! I think everyone should save it to their hard drive for future reference in case it dissapears from the web.
Bob
Lyon
Family Elder
 
Posts: 6063
Joined: Wed May 03, 2006 3:00 pm

Postby TonyJegs » Tue Mar 20, 2007 6:46 pm

Thanks for the link.
Beautiful presentation, all credits to Germans :)

I somehow don't wonder why they still promote autoimmunity of MS.

To make story short, when you see how many participants (agents) involved in MS, you wonder: is it possible to affect Toyota palnt assembly line by removing or changing one single screw?

Kind regards,
Tony
User avatar
TonyJegs
Family Member
 
Posts: 90
Joined: Sat Mar 17, 2007 4:00 pm
Location: Illinios (+ Europe)


Return to Drug Pipeline

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users