Laquinimod trial results

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bromley
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Laquinimod trial results

Post by bromley »

Don't appear that impressive - but it's oral.

http://c.moreover.com/click/here.pl?j913561424&w=464753
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dignan
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Post by dignan »

I think what Teva is most interested in is finding out in a phase 3 trial how well laquinimod plays with copaxone.
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mjs
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Re: Laquinimod trial results

Post by mjs »

bromley wrote:Don't appear that impressive - but it's oral.
Unimpressive is definitely the right description. Even drugs that reduce lesions *and* relapses are unimpressive - all this drug does is reduce lesions by a mere 38%.

They also say:
Significant differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).
...which is quite offensive really. What it should say is:
STATISTICALLY INSIGNIFICANT differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).
The "p=" part must always be <0.05. P values of 0.21, 0.33 and 0.14 mean the data is completely and utterly meaningless.

It's like saying that a glass of water a day has a significant impact on MS, however, there is a high probability this may be false.
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TonyJegs
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Re: Laquinimod trial results

Post by TonyJegs »

mjs wrote: ...which is quite offensive really. What it should say is:
STATISTICALLY INSIGNIFICANT differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).
The "p=" part must always be <0.05. P values of 0.21, 0.33 and 0.14 mean the data is completely and utterly meaningless.

It's like saying that a glass of water a day has a significant impact on MS, however, there is a high probability this may be false.
Good work, and thank you the post.

Kind regards,
Tony
"All truth passes through three stages.
First it is ridiculed.
Second it is violently opposed.
Third it is accepted as being self-evident."
Schopenhauer
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