Laquinimod trial results

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Laquinimod trial results

Postby bromley » Tue May 01, 2007 2:32 pm

Don't appear that impressive - but it's oral.

http://c.moreover.com/click/here.pl?j913561424&w=464753
User avatar
bromley
Family Elder
 
Posts: 1887
Joined: Fri Sep 10, 2004 3:00 pm

Advertisement

Postby dignan » Tue May 01, 2007 3:57 pm

I think what Teva is most interested in is finding out in a phase 3 trial how well laquinimod plays with copaxone.
User avatar
dignan
Family Elder
 
Posts: 1608
Joined: Wed Aug 11, 2004 3:00 pm

Re: Laquinimod trial results

Postby mjs » Tue May 01, 2007 9:51 pm

bromley wrote:Don't appear that impressive - but it's oral.


Unimpressive is definitely the right description. Even drugs that reduce lesions *and* relapses are unimpressive - all this drug does is reduce lesions by a mere 38%.

They also say:
Significant differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).


...which is quite offensive really. What it should say is:
STATISTICALLY INSIGNIFICANT differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).


The "p=" part must always be <0.05. P values of 0.21, 0.33 and 0.14 mean the data is completely and utterly meaningless.

It's like saying that a glass of water a day has a significant impact on MS, however, there is a high probability this may be false.
User avatar
mjs
Family Member
 
Posts: 42
Joined: Wed Jan 17, 2007 4:00 pm

Re: Laquinimod trial results

Postby TonyJegs » Wed May 02, 2007 4:18 pm

mjs wrote:...which is quite offensive really. What it should say is:
STATISTICALLY INSIGNIFICANT differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).


The "p=" part must always be <0.05. P values of 0.21, 0.33 and 0.14 mean the data is completely and utterly meaningless.

It's like saying that a glass of water a day has a significant impact on MS, however, there is a high probability this may be false.


Good work, and thank you the post.

Kind regards,
Tony
"All truth passes through three stages.
First it is ridiculed.
Second it is violently opposed.
Third it is accepted as being self-evident."
Schopenhauer
User avatar
TonyJegs
Family Member
 
Posts: 90
Joined: Sat Mar 17, 2007 4:00 pm
Location: Illinios (+ Europe)


Return to Drug Pipeline

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users