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bromley
 Post subject: Laquinimod trial results
PostPosted: Tue May 01, 2007 2:32 pm 
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Don't appear that impressive - but it's oral.

http://c.moreover.com/click/here.pl?j913561424&w=464753
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dignan
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PostPosted: Tue May 01, 2007 3:57 pm 
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I think what Teva is most interested in is finding out in a phase 3 trial how well laquinimod plays with copaxone.
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mjs
PostPosted: Tue May 01, 2007 9:51 pm 
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bromley wrote:
Don't appear that impressive - but it's oral.


Unimpressive is definitely the right description. Even drugs that reduce lesions *and* relapses are unimpressive - all this drug does is reduce lesions by a mere 38%.

They also say:
Quote:
Significant differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).


...which is quite offensive really. What it should say is:
Quote:
STATISTICALLY INSIGNIFICANT differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).


The "p=" part must always be <0.05. P values of 0.21, 0.33 and 0.14 mean the data is completely and utterly meaningless.

It's like saying that a glass of water a day has a significant impact on MS, however, there is a high probability this may be false.
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TonyJegs
PostPosted: Wed May 02, 2007 4:18 pm 
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mjs wrote:
...which is quite offensive really. What it should say is:
Quote:
STATISTICALLY INSIGNIFICANT differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0.52 +/- 0.92 vs. placebo 0.77 +/- 1.25; p = 0.21), relapse-free subjects (70.8 percent vs. 62.7 percent; p = 0.33) and time to first relapse (p = 0.14).


The "p=" part must always be <0.05. P values of 0.21, 0.33 and 0.14 mean the data is completely and utterly meaningless.

It's like saying that a glass of water a day has a significant impact on MS, however, there is a high probability this may be false.


Good work, and thank you the post.

Kind regards,
Tony

_________________
"All truth passes through three stages.
First it is ridiculed.
Second it is violently opposed.
Third it is accepted as being self-evident."
Schopenhauer
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Board index » Multiple Sclerosis » Drug Pipeline

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