Thanks for the link Ian........wait a minute.....When I've smartened up?? I've been in Florida in July and I have smartened up enough NOT to do that again! At this time of the year the average temperature in Naples is about 3 degrees cooler than the surface of the sun.bromley wrote: Unfortunately, there is a strict dress code and shiny shirts are barred. Perhaps when you've smartened yourself up we can meet up some time in the future.
Thanks for not mentioning the tarantulas, vampire bats and monitor lizards Brock. We don't want our English guest to shy away from Naples!viper498 wrote:Watch out for the mosquitos. They are horrible in that part of Florida. Even more so when you get close to the Everglades and Marco Island. I am a big guy and I am pretty sure I would be bloodless with in 30 minutes if I stood around in the Everglades. They are so big that their bites feel like Rebif injections.
P.S. Bob and I are planning to drive down and find you. Shiny shirts and all. I hope that is ok
Ian has mentioned his love of the outdoors, I think he'd enjoy snipe hunting!viper498 wrote:Indeed! What a great time we will have with Ian! Perhaps we could take him snipe hunting in the Everglades?
Lyon wrote:Hi Jean,
In reality what is considered the total "immune system" consists of a lot more than what we, who are concerned with MS consider it, but in the field of MS the lymphocytes ARE the immune system and the bone marrow is the parent....the creator of the immune system.
What you're talking about, a total reboot (or the attempt) has been used on luekemia since the 1960's and was based on the assumption that the MS process is also reciprocated in the bone marrow, which would also have to be eliminated and re-created. The total reboot was the first thing that came to the minds of researchers and it's what they were familiar with. In truth, the lead researcher in the Stony Brook cyclophosphamide study is an oncologist and not the expected neurologist.
Because the preponderance of abstracts/studies DO NOT reflect the results of simple lymphocyte elimination, almost the easiest thing to do is to read the wrong information and come to an incorrect conclusion.
Considering that only killing the lymphocytes is much less dangerous and more effective, I'm not sure why, in the case of MS, anyone would continue to consider the greatly added risks of stem cell transplant. Sure, I can see it with cancer where the problems are generated in the bone marrow but it's looking as if with MS the process is reciprocated after that point.Jean wrote: I still hope some more studies will show that total reboot is possible, but I've seen it wasn't 100 % efficient so far, whereas one could think it would be. That's why researchers are worried : if you total reboot immune system, and if you completely rebuild bone marrow with "clean" stem cells, why is the disease still active with some patients ? No answers are provided, because few studies were made, beacause the process is dangerous. (5% death risk).
Of course we've all got to form our own educated opinions but I'm personally going to find that, like many other MS "factoids" that one is a seemingly obvious but misguided "myth". There are already lots of things which could lead us to believe that progression without inflammation is a myth, but in the world of MS the direction of one's opinion totally depends which studies they decide to place their faith.Jean wrote:- Maybe Inflammation is stopped, immune attack is stopped, but axonal degeneration goes on.
You need to quit enjoying life and come around here more often Ian. You're just a hotbed of information. I found that Accentia clip interesting last night and now this one. Damn good questions by the way. I've wondered those same questions for some time......bromley wrote:Interestingly, Campath depletes T cells and B cells. Here is a response from Dr Coles to one of my questions about Campath:
although I would have liked him to specify whether or not Campath totally eliminates all T and B cells or just certain types. Not that I am in the least disenchanted with the benefits of Campath1h but I have a tendency to believe it only eliminates certain types of T and B cells.Dr Coles wrote:One explanation for the greater effectiveness of Campath-1H over antibodies that just deplete T-cells is that Campath-1H also depletes B-cells.
Users browsing this forum: No registered users