Viagra (not sex)

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Viagra (not sex)

Postby bromley » Tue Sep 04, 2007 2:58 am

I know that Viagra is used by MS patients for ED (though, of course, I don't require it). But this article claims it is being studied for neuro-protection. Lots of sex and no brain atrophy - could be a winner!

http://c.moreover.com/click/here.pl?j10 ... 7&w=464753
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Re: Viagra (not sex)

Postby Lyon » Wed Sep 05, 2007 6:13 am

bromley wrote:I know that Viagra is used by MS patients for ED (though, of course, I don't require it).
Hi Ian,
Working around the "problem" with the use of tape and popsicle sticks does NOT mean that you aren't affected by ED.

It's always seemed sensible that improved circulation would be helpful to improve/save function in the areas of brain tissue isolated by the scarring of MS lesions.

Unfortunately, if you are like me, and in this case I think you'll lie and say that you are, when the necessary amount of blood goes....."down there", it doesn't leave enough blood to power my brain.

At that point the choice becomes accepting "MS related neurodegeneration" VS "oxygen starvation related neural degeneration" so I'm not sure how much of an improvement that is :lol:

Bob
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Postby bromley » Wed Sep 05, 2007 7:21 am

Bob,

I thought you would lower the tone.

If you want some marital advice it's best to PM me (many on this site have). I was going to run a poll to see if the females on the site would find a 58 year old man, with a shiny shirt and a dodgy moustache sexually attractive - but I think I already know the answer. Good luck with the vaccum pump - I hope it works!

Ian

PS I've already met up with three attractive ladies from this site and treated them to lunch in exclusive restaurants. 3-0 to me Bob. You need to get out more - there can't be much to do in Kansas (or wherever you are from).
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Postby Lyon » Wed Sep 05, 2007 12:23 pm

bromley wrote:You need to get out more - there can't be much to do in Kansas (or wherever you are from).
OK you big bully. I'm going to halve my dose of Viagara and THEN we'll see who wins the battle of.........wits?? is that the word I'm looking for? :lol:

I need to sit down, I'm feeling faint....

Bob
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Postby Loobie » Wed Sep 05, 2007 1:37 pm

Not to make light of a serious subject (oops, you already did!), but I've got a good Cialis story to tell. We started a joint venture in Mexico City last year with a seating company. When in Mexico, you can get almost any non-narcotic drug over the counter without a prescription. Long story short, our president (who has a propencity for a rub and a tug) went out and bought some Cialis. Well he didn't read the label and the ones he bought were like 4x the strength of a regular one. He took one and we had to go get him at the "massage place". Apparently, way too much can give you some good back problems and he was locked up. It was hilarious (although I bet he wouldn't think so if his wife found out) because he was so embarrased. He is one of those who lives a life of debauchery (at least in the traditional married man sense), but thinks no one knows about it.

I would have felt sorry for anyone else, but it was just so poetic to see him walking with a major screwed up back due to a Cialis overdose (Bob don't get any ideas, it would happen to you too).
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Postby Lyon » Wed Sep 05, 2007 1:55 pm

Loobie wrote:it was just so poetic to see him walking with a major screwed up back due to a Cialis overdose (Bob don't get any ideas, it would happen to you too).
Gosh Lew, I don't think I'd ever even consider overdosing on that stuff. Messing up your back is bad enough but I have to wonder if all the excess pressure could also create an........explosion?
Bob
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Postby Lyon » Thu Sep 06, 2007 4:17 pm

Sadly there is never "proof positive" when it comes to MS, but with it in mind that the optic nerves and spine are considered extensions of the brain, and remembering the original subject of this thread....
Bob

Assessment of blood flow velocity in eyeball arteries in multiple sclerosis patients with past retrobulbar optic neuritis in color Doppler ultrasonography.
Modrzejewska M, Karczewicz D, Wilk G.

Department of Ophthalmology, Pomeranian Medical University, Szczecin.

PURPOSE: The aim of the study was to evaluate blood flow velocity in eyeball arteries in affected and unaffected eyes in patients with past retrobulbar optic neuritis in the course of multiple sclerosis (MS). MATERIAL AND METHODS: Evaluation of blood flow velocity in 16 eyes of 16 patients with unilateral retrobulbar optic neuritis was performed in ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary artery (SPCA). In the arteries the following parameters have been assessed: peak systolic velocity (PSV), end-diastolic velocity (EDV), mean flow velocity (MV), indicators of peripheral vascular resistance such as Gosling Index (PI) and Pourcelot Index (RI). The obtained values have been compared to values of blood flow in the same arteries of the control group. Using Shapiro-Wilk test, mode of distribution of each parameter was analyzed. The statistic analysis has been done between group of affected eyeballs (group 1) and control group and between group of unaffected eyeballs (group 2) in multiple sclerosis patients and control group (13 individual, 26 eyes), regarding the age. The assessment was performed with the assistance of t-Student test, and in case of lack of normal distribution, by U Mann-Whitney test. Statistically significant difference was established when p value was below 0.05 (p < or = 0.05). RESULTS: Among the analyzed parameters of blood flow velocity, statistically significant disturbances in the examined eyeball arteries were found. The most significant disturbances of blood flow were found in CRA and SPCA. The affected parameters were: diminished MV velocity in OA; PSV, MV, RI in CRA and PSV, EDV, MV and RI indices in SPCA. The similar blood flow velocity disturbances were also found in unaffected eyeball arteries. CONCLUSIONS: In MS patients with past optic neuritis disturbances of ocular circulation can be observed. The statistically significant diminishing blood flow velocity parameters and vascular resistance indices in eyeball arteries may indicate alterations of blood flow. Lowering of systolic and mean velocities and resistance indices of blood flow are most expressed in CRA and SPCA. Reduction in blood flow parameters in the examined arteries occur both, in the eyes previously affected by past optic neuritis and in contra lateral, unaffected eyes.

PMID: 17725282 [PubMed - in process]
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