Progressive MS Pipeline

A board to discuss future MS therapies in early stage (Phase I or II) trials.

Re: Progressive MS Pipeline

Postby zen2010 » Sun Jan 24, 2016 12:05 pm

dignan wrote:Upon request, here are the drugs from the pipeline that are being tested for progressive forms of MS. If I've missed anything, please let me know.



Progressive MS Treatment Pipeline - September 2011

Phase 3 Trials
- Gilenya (aka FTY720 and fingolimod) (PPMS) (Novartis)
- Masitinib (SPMS and PPMS) (aka Kinavet or AB1010) (AB Science)
- Ocrelizumab (R1594) (trial for PPMS) (Genentech, Roche, Biogen)
- Revimmune (aka high dose cyclophosphamide or cytoxan) (Accentia Biopharmaceuticals) (refractory MS - includes SPMS I think, not sure about PPMS)

Phase 2 Trials
- Amiloride (Oxford University) (PPMS)
- Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)
- GEM-SP (SPMS) (Gemacbio)
- Hydroxyurea (PPMS) (S. Andrea Hospital)
- Idebenone (National Institute of Neurological Disorders and Stroke)
- Lithium (US Department of Veterans Affairs)
- Mesenchymal Stem Cells (4 trials listed in clinicaltrials.gov)
- MIS416 (progressive MS) (Innate Therapeutics)
- PI-2301 (Peptimmune)
- Pixantrone (aka BBR 2778) (SPMS) (Cell Therapeutics)
- RTL1000 (Artielle ImmunoTherapeutics)
- Zocor (aka simvastatin) (SPMS) (MS-STAT trial - UK)


Hi all,

Can anyone pls update this status?

I tried to find something on the net but didn't get anything...

Thks
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Re: Progressive MS Pipeline

Postby zen2010 » Tue Jan 26, 2016 11:52 am

I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS
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Re: Progressive MS Pipeline

Postby UWE59 » Tue Aug 02, 2016 9:50 am

zen2010 wrote:I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS


This link is not available.
Kind regards UWE
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Re: Progressive MS Pipeline

Postby NHE » Tue Aug 02, 2016 9:54 pm

UWE59 wrote:
zen2010 wrote:I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS

This link is not available.

It works for me when I click on it.
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Re: Progressive MS Pipeline

Postby zen2010 » Thu Aug 11, 2016 12:37 am

NHE wrote:
UWE59 wrote:
zen2010 wrote:I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS

This link is not available.

It works for me when I click on it.


Hi,

Forget about the previous link and try the one below:
http://www.nationalmssociety.org/Resear ... #section-0

BR
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Re: LIPOIC ACID AN OVER THE COUNTER ANTIOXIDANT, SEEN TO SLO

Postby seeva » Wed Jul 12, 2017 2:00 am

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Re: Progressive MS Pipeline

Postby zen2010 » Mon Nov 05, 2018 8:28 am

Hi,

The next treatment for SPMS (and also PPMS I guess) will probably be this one:
https://multiplesclerosisnewstoday.com/ ... -for-spms/

Expected in US in March 2019
Later (so I guess end of the year) in Europe
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Re: Progressive MS Pipeline

Postby NHE » Wed Nov 07, 2018 2:41 am

zen2010 wrote:The next treatment for SPMS (and also PPMS I guess) will probably be this one:
https://multiplesclerosisnewstoday.com/ ... -for-spms/

Expected in US in March 2019
Later (so I guess end of the year) in Europe


Regarding Siponimod, it sounds like PML could be a potential problem.

https://multiplesclerosisnewstoday.com/ ... 2-for-spms

Siponimod works by stopping the immune cells from entering the brain and spinal cord, preventing them from causing inflammation and damage to the myelin sheath.

Siponimod does this by binding to the sphingosine-1-phosphate (S1P) receptor found on the outside of immune cells, blocking its normal action. It interacts specifically with S1P receptor 1 and 5. The S1P receptor is important to trigger the release of immune cells from the lymph node and into the circulating blood. Siponimod keeps the immune cells trapped in the lymph node, slowing MS disease progression.


and...

https://mymsaa.org/publications/msresea ... siponimod/

Siponimod is a drug with a mechanism of action similar to Gilenya. Like Gilenya, it works at the S1P receptor family to block the movement of lymph cells from lymph nodes, however, siponimod appears to interact with less of the receptors than Gilenya does – with its primary actions at the S1P1 and the S1P5 receptors. Siponimod has a relatively short half-life compared to Gilenya, which means that the drug does not stay in the body as long. Researchers hope that these small differences will minimize cardiac issues.
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