Everything I have read prior, talks of how people on long term steroids go well for the first ten years, then go downhill quickly after, and meet up with the ones not on steroids. I see this as VERY different to "long term low dose steroids" its the pulses that I think will make a difference.Lyon wrote:I have always wondered if long term low dose steroids in MS would be less dangerous and nip inflammation in the bud.
Which part exactly? did he explicitly talk about regular pulsed steroids? I don't think my "research" was that in depth, I remember I also found another study that didn't share the results above (not at hand now). That' the problem with the iternet, when you look for something, its so big, your bound to find it; even if its flatly wrong, someone would have publish something that would agree with what you want to hear. and i WANT to hear of anything that will improve my EDSSgibbledygook wrote:flatly contradicts everything my neurologist has ever said
<shortened url>1: J Nat Prod. 1990 Mar-Apr;53(2):513-6.Links
The cytotoxic principles of Solanum incanum.Lin CN, Lu CM, Cheng MK, Gan KH, Won SJ.
School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
In continuation of work on Solanum incanum a new steroidal alkaloid glycoside has been isolated from the fresh berries, which is named incanumine, and characterized as O(3)-[beta-D-xylopyranosyl-(1----3glu)-[beta-D-xylopyranosyl-(1--- -4rha)- alpha-L-rhamnopyranosyl-(1----4)]-beta-D-glucopyranosyl)-solasodine++ +. Solamargine, solasodine, ursolic acid, and ursolic acid derivatives (3-O-palmitoyl ursolic acid, 3-O-crotonyl ursolic acid, 3-O-propionyl ursolic acid) exhibited significant cytotoxic effects against human PLC/PRF/5 cells in vitro. Esterification of ursolic acid with aliphatic acids clearly enhanced the cytotoxic effects against human PLC/PRF/5 cells in vitro
Not that anyone knows how this system seems to work, but I do not see it personally as "keeping steroids in your system", if anything, the exact opposite.Lyon wrote:The difference of this situation with Cure is that steroid maintenance....keeping steroids in your system might nip inflation in the bud with the idea that it's easier to keep something from happening at all than to try to control the situation after it's gotten out of hand, and it will be interesting to see if that way of doing things does indeed reduce accumulation of disability.
There was that one study that did, but I will have to find that link again later.Lyon wrote:At this point there is nothing hinting that it won't/can't
The objective of this study was to investigate the feasibility of treating relapses of multiple sclerosis (MS) at home with oral dexamethasone. Twenty-five out of 28 consecutive patients with MS who presented with a relapse of less than 2 weeks' duration were treated on an open basis with oral dexamethasone 16 mg per day (four divided doses) for 5 consecutive days. After one week, the expanded disability status scale (EDSS) had improved by one or more grades in 88% (22 patients) and after 4 weeks in 92% (23 patients). Treatment was well tolerated. We conclude that a course of oral dexamethasone 16 mg per day shortens the duration of an exacerbation in MS in a similar way as seen after high dose i.v. methylprednisolone. Although a randomized study is needed to test this treatment regimen against i.v. high dose corticosteroids, oral dexamethasone can be used in situations when i.v. therapy is difficult to apply.
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