I actually heard some forum talk about 4-AP perhaps hindering re-myelination but I wasn't worried until I came across this the other day:
6: Glia. 2004 Nov 1;48(2):156-65.
K+ channel blockade impairs remyelination in the cuprizone model.
Bacia A, Wollmann R, Soliven B.
Department of Neurology and Committee on Neurobiology, Brain Research Institute,
University of Chicago, Chicago, Illinois 60637, USA.
The adult CNS has the capacity to remyelinate following metabolic, toxic and
autoimmune demyelinating insults. In cuprizone-induced demyelination, spontaneous
remyelination occurs after the cessation of cuprizone diet. We used the cuprizone
model to investigate the role of glial K(+) channels in oligodendroglial (OLG)
regeneration and remyelination in vivo. We found that treatment with
4-aminopyridine (4-AP), a broad-spectrum K(+) channel antagonist, results in: (1)
decreased number of oligodendroglial progenitors (OP) and OLGs; (2) diminished
astrogliosis; and (3) decreased remyelination in the corpus callosum based on the
immunoreactivity to myelin basic protein (MBP), Rip monoclonal antibody, and by
electron microscopy. Our findings support the concept that glial K(+) channels
play an important role during OLG regeneration and remyelination, a crucial
factor to be considered during the development of therapeutic strategies to
facilitate recovery in demyelinating diseases and spinal cord injury.
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
PMID: 15378653 [PubMed - indexed for MEDLINE]
Primary Progressive, Onset 10 years ago at age 42, diagnosis 6 years ago, Vit D, Chinese Herbs, Exercise, yoga. So far tried antibiotics, fumaric acid and 4AP. Currently participant in the FTY720/PPMS Trial.<br />