leflunomide ( Arava )

A board to discuss future MS therapies in early stage (Phase I or II) trials.

leflunomide ( Arava )

Postby elaine » Mon Dec 14, 2009 6:35 pm

hi just got back from seeing my neuro he has asked me if i would like to go on a drug trial for leflunomide (Arava) had a quick look at the drug pipeline but could not find anything. Has anyone heard about this drug or any one on it ?
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Postby dignan » Mon Dec 14, 2009 7:02 pm

elaine, leflunomide is similar to the oral drug currently in phase 3 MS trials, teriflunomide (teriflunomide is an analog of leflunomide). Leflunomide is an approved rheumatoid arthritis drug. There have been lab/mouse studies suggesting it might be helpful in MS, but I've never seen any info on an MS trial of leflunomide. Here is a recent review article on teriflunomide that has some good information about leflunomide:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699658/
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Postby elaine » Mon Dec 14, 2009 7:36 pm

thanks dignan for your quick response, i will print this off and read it tonight.
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Postby reneelucia » Thu Mar 04, 2010 11:04 am

Hi I'm thinking of asking the doc to prescribe this anit-inflamatory off label. Can you tell me what happened. Does it work for you?
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