Pleneva

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Pleneva

Postby scoobyjude » Fri Jan 22, 2010 9:28 pm

BTG Commences Phase IIa Study Of Pleneva For Multiple Sclerosis - Quick Facts
1/21/2010 2:51 AM ET


(RTTNews) - BTG Plc (BGC.L: News ) said it commenced dosing in a European multicentre Phase IIa study of Pleneva, a novel orally administered compound under development as a potential treatment for multiple sclerosis.

According to the company, the study, in 166 patients with the relapsing-remitting form of the disease, comprises an initial 24 week double-blind, placebo-controlled dosing period followed by a 24 week open-label extension. The primary endpoint of the study is a reduction in the number of new T1 gadolinium enhanced lesions on MRI at weeks 12, 16, 20 and 24 when compared to placebo.
Dxed Jan 2006. Sx since 2002. Rebif since March 2006. "When one door closes, another opens but we often look so long and so regretfully upon the closed door that we do not see the one which has opened for us." Alexander Graham Bell
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Postby CureOrBust » Sat Jan 23, 2010 4:23 am

http://www.btgplc.com/DevelopmentPipeline/233/PlenevaBGC200134.html
In a small single-centre, double-blind, placebo-controlled clinical pilot study, an experimental Pleneva™ prototype provided clinical benefits to patients with RRMS, including decreases in both relapse rate and EDSS scores, with additional benefits seen on pain and cognitive endpoints.
Now I'm interested.
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Postby scorpion » Sat Jan 23, 2010 6:01 am

The reduction in EDSS score got my attention as well!!! Nice find scoobyjude.
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Postby dignan » Sat Jan 23, 2010 11:25 am

Thanks for the update scooby. I've got it in the pipeline under its old, less catchy name, BGC20-0134.
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Postby Suchislife » Tue Apr 26, 2011 1:41 pm

Do we know if this drug made it or not??? Is it in another phase?? I can see it has been awhile, but I am interested. I'm searching through the forum, but I can't seem to find it... Help if you can.
Thanks!
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Re: Pleneva

Postby arabia » Thu Apr 19, 2012 11:12 am

scoobyjude wrote:BTG Commences Phase IIa Study Of Pleneva For Multiple Sclerosis - Quick Facts
1/21/2010 2:51 AM ET


(RTTNews) - BTG Plc (BGC.L: News ) said it commenced dosing in a European multicentre Phase IIa study of Pleneva, a novel orally administered compound under development as a potential treatment for multiple sclerosis.

According to the company, the study, in 166 patients with the relapsing-remitting form of the disease, comprises an initial 24 week double-blind, placebo-controlled dosing period followed by a 24 week open-label extension. The primary endpoint of the study is a reduction in the number of new T1 gadolinium enhanced lesions on MRI at weeks 12, 16, 20 and 24 when compared to placebo.


any update ? please
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Re: Pleneva

Postby DougL » Thu Apr 19, 2012 11:20 am

arabia wrote:any update ? please

from the manufacturers web site

BGC20-0134 (Pleneva™) did not meet its primary or secondary endpoints in a six-month double-blind placebo-controlled Phase IIa study in patients with relapsing remitting multiple sclerosis. Data from approximately 65% of patients who have completed an optional six-month open-label study extension will be analysed to determine if any treatment effects are evident at 12 months that were not found after 6 months.
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