2018 study: Vit D & physical activity in multiple sclerosis

Using exercise and physical therapy for recovery from the effects of MS, and for maintaining physical function.

2018 study: Vit D & physical activity in multiple sclerosis

Postby jimmylegs » Wed Aug 29, 2018 11:26 am

Vitamin D and physical activity in multiple sclerosis (2018)
Objective: To investigate the effect of physical activity on Vitamin D levels in MS patients.

Background: Lower than normal vitamin D levels have been observed in multiple sclerosis (MS) patients, similar to almost all chronic diseases. Although oral supplementation increases vitamin D blood concentrations and there is a negative correlation between vitamin D levels and disease progression, no study so far could demonstrate a positive clinical effect of vitamin D supplementation. Despite this fact many MS patients take vitamin D.

Design/Methods: In the time between 15 August and 15 September, we included 40 MS patients with an EDSS score of <= 4.0 and measured physical activity by a tracking device, time spent outdoors by diary, and vitamin D blood levels. Patients did not take vitamin D supplementation before and during the study.

Results: Thirty-eight patients, 23 women and 15 men, were finally analysed. Average age was 39.9 years with women being somewhat older (42 vs. 37 years). Mean vitamin D levels were 85.54 nmol/L. Activity variables were measured, such as active time, walking distance, number of steps, outdoor time, and calorie consumption. The primary outcome was correlation between vitamin D levels and total physical activity [minutes/day] as well as outdoor time with EDSS scores as co-variate.

In multiple regression the dominant determining factor of vitamin D levels was total physical activity (standardized beta coefficient: 0.222) and there was a very weak negative correlation with outdoor time (standardized beta coefficient: −0.082). Activity was similar in women and men, but calorie consumption was higher in men (2122 vs. 1615). More detailed analyses will be presented.

Conclusions: There is a correlation between physical activity and vitamin D blood concentrations in MS patients. Physical activity has been shown to improve clinical outcome. Alternative pathways of the correlation between disease progression and vitamin D levels need to be considered.

Disclosure: Dr. Deisenhammer has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen, Genzyme-Sanofi, Merck, Novartis, Roche, TEVA-Ratiopharm. Dr. Bauer has nothing to disclose. Dr. Lechner has nothing to disclose.

without having access to full text, several questions:

re d3 exposure and serum response lag time, i want to know

-the location of the study,
-if local constraints on cutaneous synthesis were considered in study design,
-if this crew spent more/similar/less time outside between say, march and august 15 (and for that matter, whether they spent more/similar/less time engaged in physical activity over a similar period) and
-when the authors ran the serum test, in relation to d3 exposure and physical activity.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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