I am sorry about the void you must feel around you. This is what happens, because relationships shift, but there's no reason you cannot find new relationships.
Friends and family typically have no idea what you're going though. The less you tell them (unless they *genuinely* ask), the better it is. Keep your tale of woe to other MS sufferers and your therapist (hope you have one.) People do not like to listen to sad things, that's all. So instead, try to find common topics to talk about, like music, children, gardening, politics, movies, whatever, and call them. Ask them out to lunch (if you can). Ask them if you can visit, etc. The burden of the relationship is on you. And yes, you can ask them for help from time to time, for specific things (pick up some groceries, etc.) If they respond, fine. If they don't, fine.
Also a suggestion: I don't belong to any church myself, but some of them are very involved with members and they do help each other. Maybe you can make new friends there. See how they greet you when you first visit: are they helpful? Do they talk to you? If they do, it's a good sign.
If this is possible, you could check out other MS people in your area and see if any of them would be up for some fun!