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HLA-DRB1*15:01 and multiple sclerosis: a female association?

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squiffy2

Post subject: HLA-DRB1*15:01 and multiple sclerosis: a female association?

Posted: Wed Nov 30, 2011 3:45 am

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Joined: Wed Oct 14, 2009 3:00 pm
Posts: 1711

Abstract

Background: The association between multiple sclerosis (MS) and the HLA-DRB1*15:01 haplotype has been proven to be strong, but its molecular basis remains unclear. Vitamin D receptor (VDR) gene variants and sex have been proposed to modulate this association.

Objectives: 1) Test the association of MS with *15:01 and VDR variants; 2) check whether VDR variants and/or sex modulate the risk conferred by *15:01; 3) study whether *15:01, VDR variants and/or sex affect HLA II gene expression.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1347

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