Vitamin D levels are frequently low in those with multiple sclerosis
Lisette wrote:I recently had my DNA tested, for ancestry reasons. To my surprise I have a higher than average Neanderthal percentage, I didn't even realize that this was included in the test. Anyways, after finding this out, I found information about this dna being linked to autoimmune disease. At my last visit to my neurologist, they confirmed that they were aware of this knowledge. So, I wonder is this the culprit, mixed with other factors , to come up with the perfect storm of MS? But, what are the other factors? I have a nephew and two first cousins with MS, all living in the same local environment, which I suppose is a lot higher than average, but what makes us different from the rest of the family?
. (2011)http://www.greenmedinfo.com/article/vit ... -sclerosis
CONCLUSION: 25-OH vit D serum level is very low in MS, mainly in RR-SP and PP MS and is correlated with disability. This suggests MS patients should be screened for vitamin D deficiency
and given supplementation systematically when hypovitaminosis D is discovered.
Canadian researchers8 recently reconfirmed the link between vitamin D deficiency and MS, noting that patients who have genetic variations that cause them to have low vitamin D levels
are far more likely to develop the disease. (So far, four genetic variations have been found that appear to cause low vitamin
According to co-author Dr. Brent Richards, the researchers "feel that the evidence we have supports a causal relationship, but it does not prove it." :
Genetically lowered 25OHD level is associated with an increase in the risk of MS in people of European descent.http://www.greenmedinfo.com/article/gen ... e-european
…Four SNPs were genome-wide significant for 25OHD level (p-values ranging from 6× 10-10 to 2 × 10-109), and all four SNPs lay in, or near, genes strongly implicated in separate mechanisms influencing 25OHD.
CMAJ September 1, 2015
Craig Moore, a neuroscience researcher at Memorial University of Newfoundland, questions whether vitamin D supplementation would benefit those with this type of genetic variance, saying:9
"Is their body going to do what it needs to with vitamin D? It's not going to exert the effects that it otherwise would."