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Research projects in Vinuesa’s group
Elucidating the role of the autoimmune modulator Roquin and TFH cells in the prevention of Experimental autoimmune encephalomyelitis: D. Silva, Joseph Ng, C. Vinuesa.
While mice with dysfunctional Roquin develop autoimmune diseases including diabetes, they are protected against experimental autoimmune encephalitis (EAE), a mouse model of multiple sclerosis. In this project, Joseph Ng (Honours student) and Diego Silva (Research Fellow) are studing the mechanism by which Roquin modulates the immune response in EAE and the involvement of a subset of immune cells, follicular helper T cells, in inducing protection. This work is funded by Multiple Sclerosis Research (Australia).