Multiple sclerosis risk changes with the season

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Multiple sclerosis risk changes with the season

Postby MSUK » Fri Jan 29, 2010 9:23 am

Seasonal variation in MS may be mediated by the gene HLA-DRB1 and vitamin D - http://www.msrc.co.uk/index.cfm?fuseact ... ageid=1347
MS-UK - http://www.ms-uk.org/
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Postby tara97 » Sat Jan 30, 2010 1:34 am

"Spectrum of mutations it the HFE gene implicated in haemocromatosis and porphyria." Why are they ignoring this here. Its so obvious.

http://hmg.oxfordjournals.org/cgi/conte ... t/8/8/1517
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Postby Bethr » Sat Jan 30, 2010 8:42 am

I have porphyria and one hemochromatosis C282Y gene and they thought I had MS too. I am overloading iron (that will not be picked up in a blood test because I load at low levels of ferritin) and the combination with porphyria is giving me neurological symptoms similar to MS.

My poor sister has been diagnosed with MS for 20 years, she has the genes too! You even get lesions.

When they took blood it cleared up my vein problem instantly too. I had a bleeding swollen vein in my rectum, had it for years, regular pain in the arse :lol: . It's disppeared since the blood take which would have reduced my iron overload and the excess porphyrins. No swelling, no bleeding, nothing since, blockage gone (?). It's got to be a clue to CCSVI doesn't it. I know my backside is not my brain, but a vein is a vein.
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Postby Bethr » Sat Jan 30, 2010 8:42 am

PS: I was born in the spring, so was my sister.
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Postby lyndacarol » Sat Jan 30, 2010 2:05 pm

I no longer think that vitamin D is the key factor in the geographic distribution of MS; I think that the geographic distribution and now, this issue of seasons of the year are the result of more hours of daylight, i.e., longer days. Longer periods of daylight have an impact on circadian rhythm and dependent substances, such as glucocorticoids (which increase glucose in the bloodstream and, consequently, INSULIN).

Just MY "wild and crazy" thoughts this afternoon.
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Postby lyndacarol » Fri Feb 12, 2010 7:11 pm

With my belief that glucose results in high insulin levels that then are key in MS, I found this research to be VERY interesting:

http://www.bearbiology.com/fileadmin/tpl/Downloads/URSUS/Vol_16_2/Owen_Czekala_Vol_16_2_.pdf

In my opinion, the finding that these mammals responded to an increased photoperiod with production of lower glucocorticoid levels could explain the geographic distribution of MS -- that the prevalence of MS is reduced with proximity to the equator.

I will test out this idea by using a light therapy box which offers full spectrum light. I hope it will lower my glucose and, consequently, insulin -- I will certainly report any changes I observe. This should not be tried by anyone on doxycycline or another tetracycline; doxycycline information warns against exposure to sun or artificial light.
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Postby ttt1 » Sat Feb 13, 2010 6:22 am

tara97 wrote:HMG.OXFORDJOURNALS.ORG/EGI/CONTENT/FULL/8/8/1517


some links are case sensitive
http://hmg.oxfordjournals.org/cgi/conte ... t/8/8/1517
would no longer work if you changed e.g. content to Content
( & you don't have to retype, just press Ctrl+A, Ctrl+C in address bar, Ctrl+V where you want address to appear; or use right mouse button "select all", "copy", "paste" )
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