There has never been a concrete, scientifically defined association between lesions and symptoms yet, despite the fact that all MS drugs are "lesion oriented". Neurons, oligodentrocytes and other kinds of neural cells may die without the presence of inflammation. Tysabri is potent at preventing inflammation, but can not do anything for the rest of the aspects of MS. Inflammation is a double edged knife. It has a destructive and a protective face. The whole MS hting is extremely complicated and science can not answer everything, yet.
Perhaps a very long shot, but it seems that oxidation plays a role in the whole situation. Could you try some very potent antioxidants or iron chelators? Some will strongly disagree here, but can you be checked for CCSVI?
My best wishes, my friend.
Shortest joke: "We may not be able to cure MS but we can manage its symptoms."